MABF290

Anti-S100A9 Antibody, clone 2A5 (Azide Free)

clone 2A5, 1 mg/mL, from rat

• Synonim(y): Protein S100-A9, Calgranulin-B, Leukocyte L1 complex heavy chain, Migration inhibitory factor-related protein 14, MRP-14, p14, S100 calcium-binding protein A9
• Kod UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Właściwości

• pochodzenie biologiczne: rat
• Poziom jakości: 100
• forma przeciwciała: purified antibody
• rodzaj przeciwciała: primary antibodies
• klon: 2A5, monoclonal
• reaktywność gatunkowa: human, mouse
• stężenie: 1 mg/mL
• metody: activity assay: suitable; western blot: suitable
• izotyp: IgG1
• numer dostępu NCBI: NP_00126878
• numer dostępu UniProt: P31725
• Warunki transportu: wet ice
• docelowa modyfikacja potranslacyjna: unmodified
• informacje o genach: human ... S100A9(6280)

Opis

Opis ogólny

S100A9, also known as Calgranulin-B, Leukocyte L1 complex heavy chain, Migration inhibitory factor-related protein 14, MRP-14, p14, or S100 calcium-binding protein A9, and encoded by the gene S100A9/CAGB/MRP14/S100-A9 is a calcium and zinc binding protein that plays a prominent role in the regulation of inflammatory processes and immune responses. S100-A9 can induce neutrophil chemotaxis and adhesion. S100-A9 one of the subunits of Calprotectin, which is a complex of S100-A8 and S100-A9 proteins and is also critical for immune responses. S100-A9 is a cytoplasmic and secreted protein predominantly expressed in myeloid cells as well as neutrophils and monocytes but not expressed in lymphocytes. S100-A9 is found in high concentrations at sites of inflammation or in the serum of patients with inflammatory diseases. S100-A9 is also a cancer marker as it is up regulated in many cancers including gastric, esophageal, colon, breast and many more.

Immunogen

Recombinant protein corresponding to mouse S100A9.

Zastosowanie

Activity Assay Analysis: A representative lot detected S100A9 and found that it increases neutrophil migration & induces the secretion of cytokines by monocytes (Cesaro, A., et al. (2012). PLOS ONE. 7(9):e45478 1-12).
Western Blotting Analysis: A representative lot detected S100A9 in mouse neutrophils and recombinant mS100A9 (Cesaro, A., et al. (2012). PLOS ONE. 7(9):e45478 1-12).

Anti-S100A9 Antibody, clone 2A5 (Azide Free) is an antibody against S100A9 for use in western blotting & activity assay.

Jakość

Evaluated by Western Blotting in Raji cell lysate.

Western Blotting Analysis: 2.0 µg/mL of this antibody detected S100A9 in 10 µg of Raji cell lysate.

Opis wartości docelowych

~15 kDa observed

Postać fizyczna

Format: Purified

Purified rat monoclonal IgG1 in buffer containing PBS without preservatives.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 12 - Non Combustible Liquids
• Klasa zagrożenia wodnego (WGK): WGK 2
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable