MAB810R
Anti-Cytomegalovirus Antibody, clone 8B1.2
clone 8B1.2, Chemicon®, from mouse
Synonim(y):
CMV
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About This Item
Kod UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Polecane produkty
pochodzenie biologiczne
mouse
Poziom jakości
forma przeciwciała
purified immunoglobulin
rodzaj przeciwciała
primary antibodies
klon
8B1.2, monoclonal
reaktywność gatunkowa
human
producent / nazwa handlowa
Chemicon®
metody
ELISA: suitable
flow cytometry: suitable
immunofluorescence: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable
izotyp
IgG2a
Warunki transportu
wet ice
Powiązane kategorie
Opis ogólny
Human cytomegalovirus (HCMV) is a ubiquitous human pathogen that belongs to the herpes adenovirus family. The viral life cycle takes approximately seventy two hours. After the initial fusion of the viral envelope with the plasma membrane of the cell, the encapisidated virus particle is released into the cytoplasm and within minutes, transits to the nucleus. Via active transport through the nuclear pore, the capsid gains entry and viral DNA is deposited. Viral gene expression then occurs in a temporally regulated manner, first with expression of the immediate early genes, followed by the early genes, then, after viral replication has commenced, the late genes. All of the immediate early proteins have been shown to be transactivators, with IE1-72 and IE2-86 being the most well characterized. These genes regulate the expression of factors required for virus replication.
Specyficzność
Reacts with an immediate early non-structural antigen of 68-72 kDa. This antigen can be detected 1 hour after infection exhibiting an intranuclear staining pattern. This staining reaches a peak at 10-12 hours. This antigen persists and can be detected throughout the complete CMV infection cycle.
Immunogen
Affinity purified immediate early antigen from MRC-5 cells infected with CMV AD169 (ATCC).
Zastosowanie
Anti-Cytomegalovirus Antibody, clone 8B1.2 detects level of Cytomegalovirus & has been published & validated for use in ELISA, FC, IF, IH(P) & WB.
ELISA
Western Blot: 1:200. Recognizes approximately a 70kDa band.
Immunofluorescence: 1:200-1:400.
Immunohistochemistry 1:200-1:800.
Works on paraffin embedded tissue sections.
FACS
Optimal working dilutions must be determined by end user.
Western Blot: 1:200. Recognizes approximately a 70kDa band.
Immunofluorescence: 1:200-1:400.
Immunohistochemistry 1:200-1:800.
Works on paraffin embedded tissue sections.
FACS
Optimal working dilutions must be determined by end user.
Research Category
Infectious Diseases
Infectious Diseases
Research Sub Category
Infectious Diseases - Viral
Infectious Diseases - Viral
Opis wartości docelowych
68-72 kDa
Postać fizyczna
Format: Purified
Protein A Purified mouse immunoglobulin in 20 mM sodium phosphate, 250 mM NaCl, pH. 7.6, with 0.1% sodium azide as a preservative.
Protein A purified
Przechowywanie i stabilność
Maintain for 1 year at 2–8°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Komentarz do analizy
Control
Cytomegalovirus Control Slides, Catalogue Number 5027-5
Cytomegalovirus Control Slides, Catalogue Number 5027-5
Inne uwagi
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Informacje prawne
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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polecane
Kod klasy składowania
10 - Combustible liquids
Klasa zagrożenia wodnego (WGK)
WGK 2
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.
Masz już ten produkt?
Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
No evidence of association between human cytomegalovirus infection and papillary thyroid cancer.
Huang, TS; Lee, JJ; Cheng, SP
World Journal of Surgical Oncology null
Jiri Bartek et al.
Molecular oncology, 11(8), 945-964 (2017-04-07)
Medulloblastomas are the most common, and often fatal, paediatric brain tumours that feature high genomic instability, frequent infection by human cytomegalovirus (HCMV) and resistance to radiation and chemotherapy. The causes of the pronounced chromosomal instability and its potential links with
Aldi Pupuleku et al.
Frontiers in immunology, 8, 1317-1317 (2017-11-09)
Human cytomegalovirus (HCMV) infection promotes the differentiation and persistent expansion of a mature NK cell subset, which displays high surface levels of the activating CD94/NKG2C NK cell receptor, together with additional distinctive phenotypic and functional features. The mechanisms underlying the
Human cytomegalovirus clinical strain-specific microRNA miR-UL148D targets the human chemokine RANTES during infection.
Kim, Y; Lee, S; Kim, S; Kim, D; Ahn, JH; Ahn, K
PLoS Pathogens null
Glycoprotein B (gB) vaccines adjuvanted with AS01 or AS02 protect female guinea pigs against cytomegalovirus (CMV) viremia and offspring mortality in a CMV-challenge model.
Schleiss, MR; Choi, KY; Anderson, J; Mash, JG; Wettendorff, M; Mossman, S; Van Damme, M
Vaccine null
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