MAB348

Anti-Beta (β)-Amyloid antibody

CHEMICON^®, mouse monoclonal, 22C11

• Synonim(y): APP, Anti - APP A4, Anti-amyloid precursor protein A4
• Kod UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Właściwości

• Nazwa produktu: Anti-APP A4 Antibody, a.a. 66-81 of APP {NT}, clone 22C11, clone 22C11, Chemicon^®, from mouse
• pochodzenie biologiczne: mouse
• Poziom jakości: 100
• forma przeciwciała: purified immunoglobulin
• rodzaj przeciwciała: primary antibodies
• klon: 22C11, monoclonal
• reaktywność gatunkowa: rat, fish, human, mouse, canine, pig, monkey
• producent / nazwa handlowa: Chemicon^®
• metody: immunofluorescence: suitable; immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable; western blot: suitable
• izotyp: IgG1
• numer dostępu NCBI: NM_000484.2; NM_201413.1; NM_201414.1
• numer dostępu UniProt: P05067
• Warunki transportu: dry ice
• docelowa modyfikacja potranslacyjna: unmodified
• informacje o genach: human ... APP(351)

Opis

Opis ogólny

The β/A4 amyloid precursor protein (APP) is a transmembrane glycoprotein and exists in three isoforms. This protein is composed of a single-pass transmembrane domain, a large extracellular N-terminal domain, and a short cytoplasmic C-terminal tail. The APP gene is located on the human chromosome at 21q21.3-q22.

Specyficzność

Anti-APP A4 Antibody reacts with pre-A4 and recognizes amino acids 66-81 of the N-terminus on the pre-A4 molecule (Hilbich et al., 1993). 22C11 recognizes all three isoforms of APP, immature ~110kDa, sAPP ~120kDa, and mature ~130kDa (Hoffmann et al., 2000). The Anti-APP A4 antibody is known to cross-react with APLP2 (Slunt, 1994).

Immunogen

Epitope: a.a. 66-81 of APP {N-terminus}

Purified recombinant Alzheimer precursor A4 (pre A4695) fusion protein.

Zastosowanie

Anti-APP A4 Antibody, a.a. 66-81 of APP , clone 22C11 has been used in immunohistochemistry and immunoblotting(1:1000).

Działania biochem./fizjol.

The β/A4 amyloid precursor protein (APP) undergoes proteolytic cleavage and produces β/A4 peptide. The extracellular deposition of this peptide is observed in brain cortical parenchyma and cerebro-meningeal blood vessels which marks the pathological condition of Alzheimer′s disease. Mutations of the APP gene lead to the early onset of Alzheimer′s disease and hereditary cerebral hemorrhage with amyloidosis.

Opis wartości docelowych

110/120/130 kDa

Postać fizyczna

Format: Purified

Protein A Purified mouse immunoglobulin in 20 mM sodium phosphate, 250 mM NaCl, pH. 7.6, with 0.1% sodium azide as a preservative.

Protein A purified

Przechowywanie i stabilność

Maintain for 1 year at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Komentarz do analizy

Control
Brain tissue, brain cell lysates

Inne uwagi

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informacje prawne

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 12 - Non Combustible Liquids
• Klasa zagrożenia wodnego (WGK): WGK 2
• Temperatura zapłonu (°C): Not applicable