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EZHS40

Millipore

Human Amyloid β40 ELISA Kit

measures and quantifies Amyloid β40 levels in 50 μL CSF, cell culture supernatent or plasma

Synonim(y):

Białko amyloidu-beta 40

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About This Item

Kod UNSPSC:
12161503
eCl@ss:
32161000
NACRES:
NA.84

Nazwa produktu

High Sensitivity Human Amyloid β40 ELISA, This High Sensitivity Human Amyloid β40 ELISA is used to measure & quantify Amyloid β40 levels in Neuroscience research.

Poziom jakości

200

reaktywność gatunkowa

human

opakowanie

kit of 1 × 96 wells

Parametry

50 μL sample volume (Overnight assay)

assay range

sensitivity: 6.0 pg/mL
(50 μl sample size)
standard curve range: 16-500 pg/mL

metody

ELISA: suitable

moc wejściowa

sample type plasma (K2 EDTA)
sample type serum
sample type cerebrospinal fluid (CSF)

Zastosowanie

research use

metoda wykrywania

colorimetric (450nm/590nm)

Warunki transportu

wet ice

temp. przechowywania

2-8°C

informacje o genach

human ... APP(351)

Opis ogólny

Amyloid beta peptides have been implicated in the etiology of Alzheimer’s disease. Amyloid beta 40 is the most prominent peptide and Amyloid beta 42 is the neurotoxic form. The Amyloid beta 42/40-ratio (AB ratio) has been reported as a better indicator of the Alzheimer pathology. Millipore’s High Sensitivity Human Amyloid β40 ELISA kit is used for the measurement of Amyloid β40 in cerebrospinal fluid, cell culture supernatants, primary neurons and plasma in a 96-well format.

Specyficzność

The Amyloid β40 ELISA (HS) uses monoclonal anti-Aβ antibodies with high selectivity for human Aβ. The capture antibody recognizes the C-terminal end of Amyloid β1-40, which causes a high selectivity for Aβ 40. The cross-reactivity of the used antibodies to other Amyloid peptides was tested by ELISA and BIACORE and shows no significant cross-reactivity to Aβ1-38, Aβ1-39, Aβ1-42, Aβ1-43 and Aβ1-44.

Zastosowanie

Research Category
Neuroscience
Research Sub Category
Alzheimer′s Disease
This High Sensitivity Human Amyloid β40 ELISA is used to measure & quantify Amyloid β40 levels in Neuroscience research.
This assay requires 50 µl of sample (cerebrospinal fluid, cell culture supernatants, primary neurons, or plasma) and is an overnight assay.
Used to detect/quantify: Amyloid β40

Przechowywanie i stabilność

Components in the kit can be stored up to 2 weeks at 2-8°C

Inne uwagi

Please contact Technical Service for linearity of dilution.

Oświadczenie o zrzeczeniu się odpowiedzialności

For research use only. Not for use in diagnostic procedures.
Ta strona może zawierać tekst przetłumaczony maszynowo.

Piktogramy

CorrosionExclamation mark
GHS05,GHS07

Hasło ostrzegawcze

Warning

Zwroty wskazujące rodzaj zagrożenia

H290,H317,H412

Zwroty wskazujące środki ostrożności

P234 - P261 - P272 - P273 - P280 - P302 + P352

Klasyfikacja zagrożeń

Aquatic Chronic 3 - Met. Corr. 1 - Skin Sens. 1

Kod klasy składowania

8A - Combustible corrosive hazardous materials

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Gunjan Manocha et al.
Current Alzheimer research, 15(12), 1123-1135 (2018-08-03)
Alzheimer's disease (AD) is associated with age-associated central nervous system degeneration and dementia. This decline in the function correlates with deposition of Aβ peptide containing plaques and associated reactive gliosis. The inflammatory phenotype of microglia, in particular, is often considered
Nataliya Golovyashkina et al.
Molecular neurodegeneration, 10, 60-60 (2015-11-07)
Dendritic simplification, a key feature of the neurodegenerative triad of Alzheimer's disease (AD) in addition to spine changes and neuron loss, occurs in a region-specific manner. However, it is unknown how changes in dendritic complexity are mediated and how they
Kendra L Puig et al.
Journal of Alzheimer's disease : JAD, 44(4), 1263-1278 (2014-11-20)
Alzheimer's disease (AD) is a neurodegenerative disorder histologically characterized by amyloid-β (Aβ) protein accumulation and activation of associated microglia. Although these features are well described in the central nervous system, the process and consequences of Aβ accumulation in the enteric
Anna Bogstedt et al.
Journal of Alzheimer's disease : JAD, 46(4), 1091-1101 (2015-09-25)
Utilizing decision making biomarkers in drug development requires thorough assay validation. Special considerations need to be taken into account when monitoring biomarkers using immunoassays in the presence of therapeutic antibodies. We have developed robust and sensitive assays to assess target
Loukia Katsouri et al.
Neurobiology of aging, 34(4), 1105-1115 (2012-10-16)
Noradrenergic deficits have been described in the hippocampus and the frontal cortex of Alzheimer's disease brains, which are secondary to locus coeruleus degeneration. Locus coeruleus is the brain stem nucleus responsible for synthesis of noradrenaline and from where all noradrenergic
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