ABS55

Anti-InsP3R Antibody, Type 1

from rabbit, purified by affinity chromatography

• Synonim(y): inositol 1,4,5-triphosphate receptor, type 1, spinocerebellar ataxia 16, inositol 1,4,5-trisphosphate receptor type 1, Type 1 inositol 1,4,5-trisphosphate receptor, Type 1 InsP3 receptor, IP3 receptor, spinocerebellar ataxia 15, IP3 receptor isoform 1
• Kod UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Właściwości

• pochodzenie biologiczne: rabbit
• Poziom jakości: 100
• forma przeciwciała: affinity isolated antibody
• rodzaj przeciwciała: primary antibodies
• klon: polyclonal
• oczyszczone przez: affinity chromatography
• reaktywność gatunkowa: rat, human, pig
• reaktywność gatunkowa (przewidywana na podstawie homologii): mouse (based on 100% sequence homology), rhesus macaque (based on 100% sequence homology), primate (based on 100% sequence homology), porcine (based on 100% sequence homology)
• metody: immunohistochemistry: suitable (paraffin); immunoprecipitation (IP): suitable; western blot: suitable
• numer dostępu NCBI: NP_001007236
• numer dostępu UniProt: P29994
• Warunki transportu: wet ice
• docelowa modyfikacja potranslacyjna: unmodified
• informacje o genach: human ... ITPR1(3708)

Opis

Opis ogólny

The inositol (1,4,5)-trisphosphate receptor (InsP3R) regulates calcium release from storage within cells and plays an important role in neuronal function. InsP3R has been linked to Huntington’s disease. InsP3R has also been linked to the association between cAMP and Ca2+ signaling in regions of the brain, including the neostriatum.

Specyficzność

This antibody recognizes InsP3R at the cytoplasmic domain.

Immunogen

KLH-conjugated linear peptide corresponding to the cytoplasmic domain of rat InsP3R.

Zastosowanie

Immunohistochemistry Analysis: 1:1500 dilution from a previous lot detected InsP3R in purkinje cells at the junction of the granular and molecular layers of normal rat cerebellum tissue.

Immunoprecipitation Analysis: 10 µg of Anti-InsP3R, Type 1 immunoprecipitated InsP3R, Type 1 from rat brain microsomal prep RIPA lysate.

This Anti-InsP3R Antibody, Type 1 is validated for use in WB, IP, IH(P) for the detection of InsP3R.

Jakość

Evaluated by Western Blot in rat brain microsomal tissue lysate.

Western Blot Analysis: 0.1 µg/mL of this antibody detected InsP3R on 10 µg of rat brain microsomal tissue lysate.

Opis wartości docelowych

~300 kDa observed. UniProtKB/Swiss-Prot P29994 (ITPR1_RAT) entry describes 8 isoforms produced by alternative splicing: Isoform 1 at 313.264 kDa, Isoform 2 at 311.498 kDa, Isoform 3 at 313.136 kDa, Isoform 4 at 311.370 kDa, Isoform 5 at 311.210 kDa, Isoform 6 at 309.444 kDa, Isoform 7 at 308.674 kDa, and Isoform 8 at 306.909 kDa

Inne uwagi

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 12 - Non Combustible Liquids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable