ABS445

Anti-Caspase-5 Antibody

from rabbit, purified by affinity chromatography

• Synonim(y): Caspase-5, CASP-5, ICE(rel)-III, Protease ICH-3, Protease TY, Caspase-5 subunit p202.Caspase-5 subunit p10
• Kod UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Właściwości

• pochodzenie biologiczne: rabbit
• Poziom jakości: 100
• forma przeciwciała: affinity isolated antibody
• rodzaj przeciwciała: primary antibodies
• klon: polyclonal
• oczyszczone przez: affinity chromatography
• reaktywność gatunkowa: human
• metody: immunocytochemistry: suitable; immunofluorescence: suitable; western blot: suitable
• numer dostępu UniProt: P51878
• Warunki transportu: wet ice
• docelowa modyfikacja potranslacyjna: unmodified
• informacje o genach: human ... CASP5(838)

Opis

Opis ogólny

Caspase-5 (CASP5) is a member of the peptidase C14A family that can be divided into the apoptotic and inflammatory caspase subfamilies. Members of this subfamily include caspase-1, -4, -5, and -12. When activated, these caspases result in the cleavage and activation of proinflammatory cytokines such as IL-1beta and IL-18. Caspase-5 is expressed in barely detectable amounts in most tissues except brain, with highest levels being found in lung, liver and skeletal muscle. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts.

Specyficzność

This antibody recognizes the intermediate domain of Caspase-5.

Immunogen

Epitope: Intermediate domain

KLH-conjugated linear peptide corresponding to the intermediate domain of human Caspase-5.

Zastosowanie

Detect Caspase 5 using this rabbit polyclonal antibody, Anti-Caspase-5 Antibody validated for use in western blotting, ICC & Immunofluorescence.

Immunocytochemistry Analysis: 2 µg/mL from a representative lot detected Caspase-5 in P815 cells.

Immunofluorescence Analysis: 2 µg/mL from a representative lot detected Caspase-5 in P815 cells.

Research Category
Signaling

Research Sub Category
Developmental Signaling

Jakość

Evaluated by Western Blotting in Ramos cell lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected Caspase-5 in Ramos cell lysate.

Opis wartości docelowych

~48 kDa observed. Uncharacterized bands may appear in some lysates.

Postać fizyczna

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Przechowywanie i stabilność

Stable for 1 year at 2-8°C from date of receipt.

Komentarz do analizy

Control
Ramos cell lysate

Inne uwagi

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 10 - Combustible liquids
• Klasa zagrożenia wodnego (WGK): WGK 2
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable