AB1555P
Anti-NMDAR2A Antibody
Chemicon®, from rabbit
Synonim(y):
N-methyl D-aspartate receptor subtype 2A, N-methyl-D-aspartate receptor subunit 2A, NMDA receptor subtype 2A, glutamate receptor, ionotropic, N-methyl D-aspartate 2A
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About This Item
Kod UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Polecane produkty
pochodzenie biologiczne
rabbit
Poziom jakości
forma przeciwciała
affinity purified immunoglobulin
rodzaj przeciwciała
primary antibodies
klon
polyclonal
oczyszczone przez
affinity chromatography
reaktywność gatunkowa
rat, human, mouse, fish
producent / nazwa handlowa
Chemicon®
metody
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
numer dostępu NCBI
numer dostępu UniProt
Warunki transportu
dry ice
docelowa modyfikacja potranslacyjna
unmodified
informacje o genach
human ... GRIN2A(2903)
Opis ogólny
NMDA (N-methyl-D-aspartate) receptors are a class of ionotropic glutamate receptors. The NMDAR channel has been shown to be involved in long term potentiation, an activity dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D).
Specyficzność
NMDAR2A. By Western blot it recognizes a 180 kDa band in rat brain membranes. Does not react with NMDAR2B or NMDAR2C. Immunolabeling is blocked by preadsorption of antibody with the immunogen.
Immunogen
C-Terminal Fusion Protein of rat NMDAR2A, aa 1253-1391.
Epitope: C-terminus
Zastosowanie
Anti-NMDAR2A Antibody is an antibody against NMDAR2A for use in IH, IP & WB.
Immunoprecipitation:
3 μg of a previous lot was used to (under appropriate conditions) quantitatively immunoprecipitate all NMDAR2A in 200 μg of rat brain.
Immunohistochemistry:
A previous lot of this antibody was used at 1:1,000-1:2,000 dilution.
Optimal working dilutions must be determined by the end user.
3 μg of a previous lot was used to (under appropriate conditions) quantitatively immunoprecipitate all NMDAR2A in 200 μg of rat brain.
Immunohistochemistry:
A previous lot of this antibody was used at 1:1,000-1:2,000 dilution.
Optimal working dilutions must be determined by the end user.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurotransmitters & Receptors
Neurotransmitters & Receptors
Jakość
Routinely evaluated by Western Blot on Rat Brain Microsomal lysates.
Western Blot Analysis: 1:500 dilution of this lot detected NMDAR2A on 10 μg of Rat Brain Microsomal lysates.
Western Blot Analysis: 1:500 dilution of this lot detected NMDAR2A on 10 μg of Rat Brain Microsomal lysates.
Opis wartości docelowych
180 kDa
Postać fizyczna
ImmunoAffinity Purified
Purified rabbit polyclonal lyophilized from ammonium bicarbonate (5 mM) so some residual salt may also be present. Reconstitute with 50 μL of PBS. Contains no preservative.
Przechowywanie i stabilność
Lyophilized material stable for 1 year at -20°C from date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up 6 months.
Handling Recommendations:
Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Handling Recommendations:
Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Komentarz do analizy
Control
NMDAR2A is present in high concentrations in the hippocampus.
NMDAR2A is present in high concentrations in the hippocampus.
Inne uwagi
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Informacje prawne
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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polecane
Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 1
Certyfikaty analizy (CoA)
Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.
Masz już ten produkt?
Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Co-Application of Corticosterone and Growth Hormone Upregulates NR2B Protein and Increases the NR2B:NR2A Ratio and Synaptic Transmission in the Hippocampus.
Mahmoud, GS; Amer, AS
Sultan Qaboos University medical journal null
X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor.
Sobolevsky, AI; Rosconi, MP; Gouaux, E
Nature null
A M Khan et al.
The American journal of physiology, 276(3), R880-R891 (1999-03-10)
Cells within the lateral hypothalamic area (LHA) are important in eating control. Glutamate or its analogs, kainic acid (KA) and N-methyl-D-aspartate (NMDA), elicit intense eating when microinjected there, and, conversely, LHA-administered NMDA receptor antagonists suppress deprivation- and NMDA-elicited eating. The
Asynchronous movements prior to pore opening in NMDA receptors.
Kazi, R; Gan, Q; Talukder, I; Markowitz, M; Salussolia, CL; Wollmuth, LP
The Journal of Neuroscience null
Relationship between availability of NMDA receptor subunits and their expression at the synapse
Prybylowski, Kate, et al
The Journal of Neuroscience, 22, 8902-8910 (2002)
Produkty
The term neurodegeneration characterizes a chronic loss of neuronal structure and function leading to progressive mental impairments.
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