559397

SB 202190

InSolution, ≥98%, p38 MAP kinase inhibitor

• Synonim(y): InSolution SB 202190, InSolution p38 MAP Kinase Inhibitor II
• Wzór empiryczny (zapis Hilla): C₂₀H₁₄FN₃O
• Numer CAS: 152121-30-7
• Masa cząsteczkowa: 331.34
• Numer MDL: MFCD00941964
• Kod UNSPSC: 12352200
• NACRES: NA.77

Właściwości

• Poziom jakości: 100
• Próba: ≥98% (HPLC)
• Postać: liquid
• siła działania: 16 nM IC₅₀; 16 nM K_i
• producent / nazwa handlowa: Calbiochem^®
• warunki przechowywania: OK to freeze; protect from light
• Warunki transportu: wet ice
• temp. przechowywania: −20°C
• InChI: 1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,23-24H
• Klucz InChI: NJNKPVPFGLGHPA-UHFFFAOYSA-N

Opis

Opis ogólny

A potent and cell-permeable inhibitor of p38 MAP kinase. Inhibits p38 phosphorylation of myelin basic protein (MBP) with no effect on the activity of the ERK or JNK MAP kinase subgroups. Also inhibits the kinase activity of p38β (IC₅₀ = 350 nM) and p38 phosphorylation of activating transcription factor 2 (ATF-2; IC₅₀ = 280 nM). Blocks LPS-induced TNF-α and interleukin biosynthesis. Reported to block LDL expression in Hep52 cells.

Działania biochem./fizjol.

Cell permeable: yes

Primary Target
P38β

Product competes with ATP.

Reversible: yes

Target K_i: 350 nM against the kinase activity of p38β; 280 nM against p38 phosphorylation of activating transcription factor 2 (ATF-2)

Opakowanie

Packaged under inert gas

Please refer to vial label for lot-specific concentration.

Ostrzeżenie

Toxicity: Irritant (B)

Postać fizyczna

A 1 mg/ml solution of SB 202190 (Cat. No. 559388) in anhydrous DMSO.

Rekonstytucja

Following initial thaw, aliquot and freeze (-20°C).

Inne uwagi

Ajizian, S.J., et al. 1999. J. Infect. Dis.179, 939.
Singh, R.P., et al. 1999. J. Biol. Chem.274, 19593.
Wang, S.W., et al. 1999. Inflamm. Res.48, 533.
Gallagher, T.F., et al. 1997. Bioorg. Med. Chem.5, 49.
Jiang, Y., et al. 1996. J. Biol. Chem.271, 17920.
Kramer, R.M., et al. 1996. J. Biol. Chem.271, 27723.
Li, Z., et al. 1996. Biochem. Biophys. Res. Commun.228, 334.
Lee, L.C., et al. 1994. Nature372, 739.

Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 10 - Combustible liquids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): 188.6 °F - closed cup - (Dimethylsulfoxide)
• Temperatura zapłonu (°C): 87 °C - closed cup - (Dimethylsulfoxide)