540213

PTP Inhibitor V, PHPS1

The PTP Inhibitor V, PHPS1, also referenced under CAS 314291-83-3, controls the biological activity of PTP. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonim(y): PTP Inhibitor V, PHPS1, 4-(Nʹ-(3-(4-Nitrophenyl)-5-oxo-1-phenyl-1,5-dihydro-pyrazol-(4Z)-ylidene)-hydrazino)-benzenesulfonic acid, PhenylHydrazonoPyrazolone Sulfonate 1, PTPNN1 Inhibitor, EC-PTP/PCPTP1 Inhibitor I, MptpA Inhibitor, PTP-SL, PhenylHydrazonoPyrazolone Sulfonate 1, PTPNN1 Inhibitor, 4-(Nʹ-(3-(4-Nitrophenyl)-5-oxo-1-phenyl-1,5-dihydro-pyrazol-(4Z)-ylidene)-hydrazino)-benzenesulfonic acid, EC-PTP/PCPTP1 Inhibitor I, MptpA Inhibitor, PTP-SL Inhibitor I, PTP1B Inhibitor V, SHP1 Inhibitor VI, SHP2 Inhibitor III
• Wzór empiryczny (zapis Hilla): C₂₁H₁₅N₅O₆S
• Numer CAS: 314291-83-3
• Masa cząsteczkowa: 465.44
• Kod UNSPSC: 12352200
• NACRES: NA.28

Właściwości

• Poziom jakości: 100
• Próba: ≥95% (HPLC)
• Postać: solid
• producent / nazwa handlowa: Calbiochem^®
• warunki przechowywania: OK to freeze; desiccated (hygroscopic); protect from light
• kolor: reddish
• rozpuszczalność: DMSO: 10 mg/mL
• Warunki transportu: ambient
• temp. przechowywania: 2-8°C

Opis

Opis ogólny

A cell-permeable phosphotyrosine mimetic that acts as a reversible, active-site targeting, substrate-competitive inhibitor of Shp-2 (IC₅₀ and K_i = 2.1 and 0.73 µM, respectively). PHPS1 inhibits ECPTP, PTP1B, Shp1, mycobacterium MptpA only at higher concentrations (IC₅₀ = 5.4, 19, 30, and 39 µM, respectively) and exhibits little activity against PTPH1, STEP, PTPN7, PTPRK, GLEPP1, or LAR2 even at concentrations as high as 50 µM. Shown to inhibit Shp-2-dependent cellular signaling and tumor cell colonies formation.

Opakowanie

Packaged under inert gas

Ostrzeżenie

Toxicity: Standard Handling (A)

Inne uwagi

Hellmuth, K., et al. 2008. Proc. Natl. Acad. Sci. USA105, 7275.

Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 2
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable