5.08321

Dihydroorotate Dehydrogenase Inhibitor, Brequinar

• Synonim(y): Dihydroorotate Dehydrogenase Inhibitor, Brequinar, 6-fluoro-2-(2ʹ-fluoro-1,1ʹ-biphenyl-4-yl)-3-methyl-4-quinoline-carboxylic acid sodium salt, NSC 368390, DuP 785, NSC 368390, DuP 785, 6-fluoro-2-(2ʹ-fluoro-1,1ʹ-biphenyl-4-yl)-3-methyl-4-quinoline-carboxylic acid sodium salt
• Wzór empiryczny (zapis Hilla): C₂₃H₁₄F₂NNaO₂
• Numer CAS: 96201-88-6
• Masa cząsteczkowa: 397.35
• Kod UNSPSC: 12352200

Właściwości

• Próba: ≥98% (HPLC)
• Poziom jakości: 100
• Postać: solid
• siła działania: 12 nM IC₅₀
• producent / nazwa handlowa: Calbiochem^®
• warunki przechowywania: OK to freeze; protect from light
• kolor: off-white
• rozpuszczalność: DMSO: 50 mg/mL
• temp. przechowywania: 2-8°C
• InChI: 1S/C23H15F2NO2.Na/c1-13-21(23(27)28)18-12-16(24)10-11-20(18)26-22(13)15-8-6-14(7-9-15)17-4-2-3-5-19(17)25;/h2-12H,1H3,(H,27,28);/q;+1/p-1
• Klucz InChI: PZOHOALJQOFNTB-UHFFFAOYSA-M

Opis

Opis ogólny

A quinolinecarboxylic acid derivative with immunosuppressive and anti-neoplastic properties. Inhibits pyrimidine synthesis by blocking the activity of mammalian mitochondrial dihydroorotate dehydrogenase (DHODH; IC₅₀ = 12 nM). Does not affect DHODH in non-mammalian species. Also reported to inhibit glycosylation of adhesion molecules. Potentiates the sensitivity of U1690 small cell lung cancer cells to TRAIL-induced apoptosis and synergistically enhances the anti-tumor effects of doxorubicin ( ~100 µM).

Działania biochem./fizjol.

Cell permeable: yes

Primary Target
DHODH

Opakowanie

Packaged under inert gas

Ostrzeżenie

Toxicity: Standard Handling (A)

Rekonstytucja

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Inne uwagi

He, T. et al. 2013. Oncogene32, in press.
Hurt, D.E., et al. 2006. Bioorg. Med. Chem. Lett.16, 1610.
Schnellrath, L. et al. 2011. Int. J. Antimicrob. Agents.38, 435.
Batt, D.G., et al. 1995. Bioorg. Med. Chem. Lett.14, 1549.
Allison, A., et al. 1993. Transplantation Proc.25, 67.
Cramer, D. et al. 1992. Transplantation.53, 303.

Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable