5.04905

Memantine Hydrochloride

• Synonim(y): Memantine Hydrochloride, 3,5-Dimethyl-1-adamantanamine hydrochloride
• Wzór empiryczny (zapis Hilla): C₁₂H₂₁N · xHCl
• Numer CAS: 41100-52-1
• Masa cząsteczkowa: 179.30 (free base basis)
• Numer MDL: MFCD00214336
• Kod UNSPSC: 12352200

Właściwości

• Próba: ≥98% (HPLC)
• Poziom jakości: 100
• Postać: solid
• producent / nazwa handlowa: Calbiochem^®
• warunki przechowywania: OK to freeze; protect from light
• kolor: white
• rozpuszczalność: H₂O: 100 mM
• temp. przechowywania: 2-8°C
• InChI: 1S/C12H21N.ClH/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10;/h9H,3-8,13H2,1-2H3;1H
• Klucz InChI: LDDHMLJTFXJGPI-UHFFFAOYSA-N

Opis

Opis ogólny

A very potent, voltage-dependent, rapidly unbinding antagonist (calcium channel blocker) of NMDA receptors (IC₅₀ = 0.8, 0.57, 0.52, and 0.54 µM for GluN2A, B, C, and D, respectively). A popular medicine for treating moderate-to-severe Alzheimer′s disease. Frequently used in studying brain functions and disorders involving neurotransmission mediated by NMDA receptors (i.e. learning and memory, cognitive functions, neuroplasticity, Alzheimer′s disease, schizophrenia, bipolar depression, obsessive-compulsive disorders, oxidative stress, and excitotoxicity).

Memantine Hydrochloride is a very potent, voltage-dependent, rapidly unbinding antagonist (calcium channel blocker) of NMDA receptors.

Działania biochem./fizjol.

Primary Target
NMDA receptors

Target IC₅₀: 0.8, 0.57, 0.52, and 0.54 →M for GluN2A, B, C, and D, respectively.

Ostrzeżenie

Toxicity: Standard Handling (A)

Rekonstytucja

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Inne uwagi

Limapichat, W., et al. 2012. ACS Chem. Neurosci.4, 255.
Anand, A., et al. 2012. Bipolar Dis.14, 64.
Lopes, P., et al. 2013. Brain and Behavior.3, 67.
Howard, R., et al. 2012. New Eng. J. Med.366, 893.
Parsons, G., et al. 1999. Neuropharmacol.38, 735.
Lee, G., et al. 2012. Psychiatry Investig.9, 166.

Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable