454586

NMDAR2C/2D Inhibitor, DQP-1105

The NMDAR2C/2D Inhibitor, DQP-1105 controls the biological activity of NMDAR2C/2D. This small molecule/inhibitor is primarily used for Neuroscience applications.

• Synonim(y): NMDAR2C/2D Inhibitor, DQP-1105, NMDA Antagonist IV, DQP-1105
• Wzór empiryczny (zapis Hilla): C₂₉H₂₄BrN₃O₄
• Numer CAS: 380560-89-4
• Masa cząsteczkowa: 558.42
• Numer MDL: MFCD02989065
• Kod UNSPSC: 12352200
• NACRES: NA.77

Właściwości

• Poziom jakości: 100
• Próba: ≥97% (HPLC)
• Postać: solid
• producent / nazwa handlowa: Calbiochem^®
• warunki przechowywania: OK to freeze; protect from light
• kolor: yellow-white
• rozpuszczalność: DMSO: 10 mg/mL, pale yellow
• Warunki transportu: ambient
• temp. przechowywania: −20°C
• ciąg SMILES: O=C(O)CCC(N1N=C(C2=C(C3=CC=CC=C3)C4=C(NC2=O)C=CC(C)=C4)CC1C5=CC=C(Br)C=C5)=O

Opis

Opis ogólny

A dihydroquinilone-pyrazoline NMDA antagonist, which is selective for NMDA receptors that are comprised of recombinant subunits GluN1/GluN2C (IC₅₀ = 5.4 µM) and GluN1/GluN2D (2.2 µM) over GluN1/GluN2B (206 µM) and GluN1/ClucN2A (undetectable) in Xenopus oocytes. Similar selectivity is observed in whole-cell HEK patch-clamp assays with IC₅₀ values for GluN2C and GluN2D that are at least 50-fold lower than those for recombinant GluN2A, GluN2B, GluA1, or GluK2-containing receptors. It inhibits NMDA by blocking a conformational change necessary for channel opening and is non-competitive with co-agonists, glutamate and glycine.

Opakowanie

Packaged under inert gas

Ostrzeżenie

Toxicity: Regulatory Review (Z)

Inne uwagi

Acker, T., et al. 2011. Mol. Pharmacol.80, 782.

Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 2
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable