454575

N-Methyl-D-aspartic Acid, Hydrate

Excitatory amino acid neurotransmitter.

• Synonim(y): N-Methyl-D-aspartic Acid, Hydrate, NMDA
• Wzór empiryczny (zapis Hilla): C₅H₉NO₄ · xH₂O
• Numer CAS: 6384-92-5
• Masa cząsteczkowa: 147.13 (anhydrous basis)
• Numer MDL: MFCD00004226
• Kod UNSPSC: 12352209

Właściwości

• Poziom jakości: 100
• Próba: >95% (TLC)
• Postać: solid
• producent / nazwa handlowa: Calbiochem^®
• warunki przechowywania: OK to freeze
• kolor: white
• rozpuszczalność: water: 1 mg/mL
• Warunki transportu: ambient
• temp. przechowywania: 10-30°C
• InChI: 1S/C5H9NO4/c1-6-3(5(9)10)2-4(7)8/h3,6H,2H2,1H3,(H,7,8)(H,9,10)/p-1/t3-/m1/s1
• Klucz InChI: HOKKHZGPKSLGJE-GSVOUGTGSA-M

Opis

Opis ogólny

An excitatory amino acid neurotransmitter. Selective agonist of the glutamate receptor that regulates Ca²⁺ channels. Important in long-term potentiation, ischemia, and epilepsy. NMDA receptors are involved in the "fine tuning" of synaptic connections in the developing brain. Chronic treatment with NMDA produces structural changes in synaptic morphology. Over-excitation of NMDA receptors causes neuronal degeneration and cell death.

Excitatory amino acid neurotransmitter. Selective agonist of the glutamate receptor that regulates Ca²⁺ channels. Important in long-term potentiation, ischemia, and epilepsy. NMDA receptors are involved in the "fine tuning" of synaptic connections in the developing brain. Chronic treatment with NMDA produces structural changes in synaptic morphology. Over-excitation of NMDA receptors causes neuronal degeneration and cell death.

Działania biochem./fizjol.

Cell permeable: no

Primary Target
Glutamate receptor that regulates Ca2+ channels

Product does not compete with ATP.

Reversible: no

Ostrzeżenie

Toxicity: Standard Handling (A)

Rekonstytucja

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for several days at 4°C.

Inne uwagi

Mattson, M.P., et al. 1993. J. Neurosci. 13, 4575.
Yen, L-H., et al. 1993. J. Neurosci. 13, 4949.
Swann, J.W., et al. 1992. Epilepsy Res. Suppl. 9, 115.

Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable