445888

Metastin (45-54)

A decapeptide with C-terminally amidated LRF-motif that acts as a potent and selective agonist of AXOR12 and hOT7T175 (a novel human G-protein-coupled receptors).

• Synonim(y): Metastin (45-54), KiSS-1 (112-121), Kisspeptin-10, H-YNWNSFGLRF-NH₂
• Wzór empiryczny (zapis Hilla): C₆₃H₈₃N₁₇O₁₄
• Masa cząsteczkowa: 1302.44
• Kod UNSPSC: 12352200
• NACRES: NA.77

Właściwości

• Poziom jakości: 100
• Próba: ≥97% (HPLC)
• Postać: lyophilized solid
• producent / nazwa handlowa: Calbiochem^®
• warunki przechowywania: OK to freeze; desiccated (hygroscopic)
• kolor: white
• rozpuszczalność: DMSO: 5 mg/mL
• Warunki transportu: ambient
• temp. przechowywania: −20°C

Opis

Opis ogólny

A decapeptide with C-terminally amidated LRF-motif that acts as a potent and selective agonist of AXOR12 and hOT7T175 (a novel human G-protein-coupled receptor). More potent than the parent peptide. Induces an increase in intracellular Ca²⁺ levels in CHO/h175 and CHO/AXOR12:Gqi5 cells and exhibits about 8-fold higher receptor binding affinity (K_i = 42 pM, determined by competitive binding analysis) as compared to Metastin (Cat. No. 444885).

A decapeptide with C-terminally amidated LRF-motif that acts as a potent and selective agonist of AXOR12 and hOT7T175 (a novel human G-protein-coupled receptors). Induces an increase in intracellular Ca²⁺ levels in CHO/h175 and CHO/AXOR12:Gqi5 cells and exhibits about 8-fold higher receptor binding affinity (K_i = 42 pM) compared to Metastin (Cat. No. 445885).

Działania biochem./fizjol.

Cell permeable: no

Primary Target
AXOR12 and hOT7T175

Product does not compete with ATP.

Reversible: no

Target K_i: 42 pM for AXOR12 and hOT7T175

Opakowanie

Packaged under inert gas

Ostrzeżenie

Toxicity: Standard Handling (A)

Sekwencja

H-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂

Inne uwagi

Kotani, M., et al. 2001. J. Biol. Chem.276, 34631.
Ohtaki, T., et al. 2001. Nature411, 613.
Muir, A.I., et al. 2001. J. Biol. Chem.276, 28969.

Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable