219379

Cathepsin K Inhibitor II

The Cathepsin K Inhibitor II controls the biological activity of Cathepsin K. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• Synonim(y): Cathepsin K Inhibitor II, Inhibitor Boc-I, 1-(N-Benzyloxycarbonyl-leucyl)-5-(N-Boc-phenylalanyl-leucyl)carbohydrazide, Z-L-NHNHCONHNH-LF-Boc
• Wzór empiryczny (zapis Hilla): C₃₅H₅₁N₇O₈
• Masa cząsteczkowa: 697.82
• Kod UNSPSC: 12352200
• NACRES: NA.77

Właściwości

• Poziom jakości: 100
• Próba: ≥95% (HPLC)
• Postać: lyophilized solid
• producent / nazwa handlowa: Calbiochem^®
• warunki przechowywania: OK to freeze
• kolor: white
• rozpuszczalność: DMSO: 1 mg/mL
• Warunki transportu: wet ice
• temp. przechowywania: −20°C

Opis

Opis ogólny

A cell-permeable peptidyl bis-carbohydrazide compound that acts as a potent, selective, and reversible inhibitor of cathepsin K (K_i,app = 6 nM). Shown to completely block cathepsin K activity in primary human synovial fibroblast cultures at 1 µM. At higher concentrations, also inhibits the activities of cathepsin B and papain (K_i,app = 510 nM, 1.2 µM, respectively). Does not significantly inhibit cathepsin L.

A cell-permeable peptidyl bis-carbohydrazide compound that acts as a potent, selective, and reversible inhibitor of cathepsin K (K_i = 6 nM). Reported to completely block cathepsin K activity in primary human synovial fibroblast cultures at a concentration of 1 µM. Also shown to inhibit the activity of cathepsin B and papain at higher concentrations (K_i = 510 nM and 1.2 µM, respectively). Does not significantly inhibit cathepsin L.

Działania biochem./fizjol.

Cell permeable: yes

Primary Target
cathepsin K

Product does not compete with ATP.

Reversible: yes

Target K_i: 6 nM against cathepsin; 510 nM, 1.2 µM, against cathepsin B and papain, respectively

Opakowanie

Packaged under inert gas

Ostrzeżenie

Toxicity: Standard Handling (A)

Sekwencja

Boc-Phe-Leu-NHNH-CO-NHNH-Leu-Z

Rekonstytucja

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Inne uwagi

Wang, D., et al. 2002. Biochemistry41, 8849.

Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable