204897

Complement C4b, Human

Complement C4b, Human, is a native, 193 kDa glycoprotein composed of the modified C4 α-chain (α′) and intact β- and γ-chains complement component.

• Kod UNSPSC: 12352202
• NACRES: NA.25

Właściwości

• Poziom jakości: 100
• Próba: ≥95% (SDS-PAGE)
• Postać: liquid
• nie zawiera: preservative
• producent / nazwa handlowa: Calbiochem^®
• warunki przechowywania: OK to freeze; avoid repeated freeze/thaw cycles
• zanieczyszczenia: IgG, IgA, IgM, Factor B, Factor H, C3, ceruloplasmin, or albumin, trace
• Warunki transportu: wet ice
• temp. przechowywania: −70°C

Opis

Działania biochem./fizjol.

Complement C4b fragment is formed by the cleavage of the C4 α-chain by activated C1 enzyme. Like C3b, C4b has the transient ability to form a covalent ester bond with a variety of target cell surfaces. Target surface-bound C4b acts as an important non-enzymatic subunit of the classical pathway C3 cleaving enzyme (C4b, C2a). This surface-bound C4b also exhibits opsonic and immune adherence activities which are dependent on the CR1 (CD35) complement receptor found on many inflammatory cells.

ComplementC4b fragment is formed by the cleavage of the C4 α-chain by activated C1enzyme. Like C3b, C4b has the transient ability to form a covalent ester bond with a variety of target cell surfaces. Target surface-bound C4b acts as an important non-enzymatic subunit of the classical pathway C3 cleaving enzyme (C4b, C2a). This surface-bound C4b also exhibits opsonic and immune adherence activities which are dependent on the CR1 (CD35) complement receptor found on many inflammatory cells.

Opakowanie

Please refer to vial label for lot-specific concentration.

Ostrzeżenie

Toxicity: Standard Handling (A)

Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 12 - Non Combustible Liquids
• Klasa zagrożenia wodnego (WGK): nwg
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable