200484-M

Bestatin

Binds to cell surfaces and inhibits surface aminopeptidases, notably aminopeptidase B and leucine aminopeptidase.

• Synonim(y): Bestatin, [(2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoyl]-Leu
• Wzór empiryczny (zapis Hilla): C₁₆H₂₄N₂O₄
• Numer CAS: 58970-76-6
• Masa cząsteczkowa: 308.37
• Numer MDL: MFCD00083262
• Kod UNSPSC: 12352200
• NACRES: NA.77

Właściwości

• Poziom jakości: 100
• Próba: >99% (HPLC)
• Postać: crystalline solid
• producent / nazwa handlowa: Calbiochem^®
• warunki przechowywania: OK to freeze
• kolor: white
• rozpuszczalność: DMSO: 2 mg/mL; methanol: 5 mg/mL
• temp. przechowywania: 2-8°C
• InChI: 1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13-,14+/m1/s1
• Klucz InChI: VGGGPCQERPFHOB-MCIONIFRSA-N

Opis

Opis ogólny

Binds to cell surfaces and inhibits surface aminopeptidases, notably aminopeptidase B and leucine aminopeptidase. Also acts as a potent aminopeptidase N inhibitor. Activates macrophages and T lymphocytes. Has anti-tumor properties. Effective at a concentration of 1-10 µM.

Binds to cell surfaces and inhibits surface aminopeptidases, notably aminopeptidase B and leucine aminopeptidase. Also acts as a potent aminopeptidase N inhibitor. Activates macrophages and T lymphocytes. Has antitumor properties. Also available as a 50 mM solution in water (Cat. No. 200488).

Działania biochem./fizjol.

Primary Target
amino peptidase b

Ostrzeżenie

Toxicity: Standard Handling (A)

Uwaga dotycząca przygotowania

Unstable in aqueous solution; dilute just prior to use.

Rekonstytucja

Following reconstitution, aliquot and freeze (-20°C). DMSO and methanol stock solutions are stable for up to 1 month at -20°C.

Inne uwagi

Inoue, T., et al. 1994. J. Clin. Endocrinol. Metab. 79, 171.
Taylor, A., et al. 1993. Biochemistry32, 784.
Ishida, J.I., et al. 1984. J. Chromatogr.305, 381.
Umezawa, H. 1982. Annu. Rev. Microbiol.36, 75.

Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable