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Key Documents

09-817

Sigma-Aldrich

Anti-JMJD1C Antibody

from rabbit, purified by affinity chromatography

Synonim(y):

JMJD, jumonji domain containing 1C, TR-interacting protein 8, thyroid receptor interacting protein 8, probable JmjC domain-containing histone demethylation protein 2C, thyroid hormone receptor interactor 8, Thyroid receptor-interacting protein 8, Jumonji

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About This Item

Kod UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

pochodzenie biologiczne

rabbit

Poziom jakości

100

forma przeciwciała

affinity isolated antibody

rodzaj przeciwciała

primary antibodies

klon

polyclonal

oczyszczone przez

affinity chromatography

reaktywność gatunkowa

human

reaktywność gatunkowa (przewidywana na podstawie homologii)

chimpanzee (based on 100% sequence homology), rhesus macaque (based on 100% sequence homology), orangutan (based on 100% sequence homology), rabbit (based on 100% sequence homology)

metody

immunocytochemistry: suitable
western blot: suitable

numer dostępu NCBI

NP_116165

numer dostępu UniProt

Q15652

Warunki transportu

wet ice

docelowa modyfikacja potranslacyjna

unmodified

informacje o genach

human ... JMJD1C(221037)

Opis ogólny

JMJD1C (jumonji domain-containing protein 1C) is also known as TRIP8 and mutations in this histone demethylase have been linked to certain forms of autism. JMJD1C is also thought to work in reactivating genes in embryonic stem cells, pancreatic islet and gastric cancer. JMJD1C has also been implicated as a gene expression regulator. JMJD1C with WHISTLE have recently been shown to also play a role in mouse testis development. JMJD1C has been identified as a nuclear-receptor coactivator and is a candidate gene for autism.

Immunogen

KLH-conjugated linear peptide corresponding to human JMJD1C.

Zastosowanie

Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected JMJD1C in HeLa cells.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Histone Modifying Proteins
Use Anti-JMJD1C Antibody (Rabbit Polyclonal Antibody) validated in WB, ICC to detect JMJD1C also known as jumonji domain containing 1C or TR-interacting protein 8.

Jakość

Evaluated by Western Blot in HeLa nuclear extract.

Western Blot Analysis: 1 µg/mL of this antibody detected JMJD1C on 10 µg of HeLa nuclear extract.

Opis wartości docelowych

~284 kDa observed

Postać fizyczna

Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Przechowywanie i stabilność

Stable for 1 year at 2-8°C from date of receipt.

Komentarz do analizy

Control
HeLa nuclear extract

Inne uwagi

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania

12 - Non Combustible Liquids

Klasa zagrożenia wodnego (WGK)

WGK 1

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Certyfikaty analizy (CoA)

Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.

Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Mauricio A Sáez et al.
Genetics in medicine : official journal of the American College of Medical Genetics, 18(4), 378-385 (2015-07-17)
Autism spectrum disorders are associated with defects in social response and communication that often occur in the context of intellectual disability. Rett syndrome is one example in which epilepsy, motor impairment, and motor disturbance may co-occur. Mutations in histone demethylases
Tim Verhagen et al.
ACS nano, 14(11), 15587-15594 (2020-10-30)
Various properties of water are affected by confinement as the space-filling of the water molecules is very different from bulk water. In our study, we challenged the creation of a stable system in which water molecules are permanently locked in
Chieko Kishi-Itakura et al.
Methods in molecular biology (Clifton, N.J.), 1759, 29-39 (2017-04-01)
In this chapter we describe the use of correlative light-electron microscopy (CLEM) to study, in cultured cells, the turnover of damaged mitochondria by PINK1/Parkin-dependent mitophagy. CLEM combines the advantages of light microscopy, which allows to image and rapidly screen a
Jiong Li et al.
Nature communications, 8, 15146-15146 (2017-04-26)
Human colorectal cancer stem cells (CSCs) are tumour initiating cells that can self-renew and are highly tumorigenic and chemoresistant. While genetic mutations associated with human colorectal cancer development are well-known, little is known about how and whether epigenetic factors specifically

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