Wszystkie zdjęcia(1)
Kluczowe dokumenty
C-059
Clozapine solution
1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
Zaloguj sięWyświetlanie cen organizacyjnych i kontraktowych
About This Item
Polecane produkty
klasa czystości
certified reference material
Poziom jakości
Formularz
liquid
Właściwości
SNAP-N-SPIKE®, SNAP-N-SHOOT®
opakowanie
ampule of 1 mL
producent / nazwa handlowa
Cerilliant®
stężenie
1.0 mg/mL in methanol
metody
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
Zastosowanie
clinical testing
Format
single component solution
temp. przechowywania
−20°C
ciąg SMILES
CN1CCN(CC1)C2=Nc3cc(Cl)ccc3Nc4ccccc24
InChI
1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
Klucz InChI
QZUDBNBUXVUHMW-UHFFFAOYSA-N
informacje o genach
human ... DRD2(1813) , HTR2A(3356)
Opis ogólny
A Certified Snap-N-Spike® Solution for use in clinical toxicology, forensic analysis, or urine drug testing applications by LC/MS or GC/MS. Clozapine, sold as Clozaril® and FazaClo® in the US, is an atypical antipsychotic drug used for treatment of schizophrenia.
Zastosowanie
- Augmentation Strategies for Clozapine Non-responders: A Bayesian network meta-analysis evaluated augmentation strategies for patients with schizophrenia who show partial or no response to clozapine, providing insights into effective secondary treatment options (Mishra et al., 2024).
- Antipsychotic Pre-treatment and Clozapine Metabolism: Research highlighted the impact of rapid metabolism of antipsychotics prior to clozapine treatment, affecting serum levels and suggesting a need for adjusted dosing strategies in treatment-resistant schizophrenia (Lenk HÇ et al., 2024).
- Genetic Influences on Clozapine Side Effects: A study identified polymorphisms in ERBB4 and TACR1 genes associated with dry mouth in patients treated with clozapine, pointing towards personalized management strategies for side effects (Puolakka et al., 2024).
- Therapeutic Mechanisms of Antipsychotics: An analysis focused on understanding the therapeutic mechanisms of antipsychotics including clozapine, examining cellular and molecular targets and their implications for optimizing treatment efficacy in psychiatric disorders (Direktor et al., 2024).
- Clozapine and Metabolic Syndrome in Schizophrenia: A study assessed the association between cytokine levels, psychopathology, and cognitive functions in clozapine-treated schizophrenia patients with metabolic syndrome, providing data critical for holistic treatment approaches (Dong et al., 2024).
Informacje prawne
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Clozaril is a registered trademark of Sandoz, Inc.
FazaClo is a registered trademark of Jazz Pharmaceuticals International III Limited
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
Ta strona może zawierać tekst przetłumaczony maszynowo.
Hasło ostrzegawcze
Danger
Zwroty wskazujące rodzaj zagrożenia
Zwroty wskazujące środki ostrożności
Klasyfikacja zagrożeń
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
Organy docelowe
Eyes,Central nervous system
Kod klasy składowania
3 - Flammable liquids
Klasa zagrożenia wodnego (WGK)
WGK 2
Temperatura zapłonu (°F)
49.5 °F - closed cup
Temperatura zapłonu (°C)
9.7 °C - closed cup
Wybierz jedną z najnowszych wersji:
Certyfikaty analizy (CoA)
Lot/Batch Number
Przepraszamy, ale COA dla tego produktu nie jest aktualnie dostępny online.
Proszę o kontakt, jeśli potrzebna jest pomoc Obsługa Klienta
Masz już ten produkt?
Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Klienci oglądali również te produkty
Chun-Hsin Chen et al.
The Journal of clinical psychiatry, 74(5), e424-e430 (2013-06-14)
Many studies have shown that metformin can decrease body weight and improve metabolic abnormalities in patients with schizophrenia. Whether or not the beneficial effects can be sustained after discontinuation of metformin needs to be evaluated. We conducted a 24-week randomized
Galvin Vredenburg et al.
Toxicology letters, 222(3), 247-256 (2013-08-07)
Clozapine, an often-prescribed antipsychotic drug, is implicated in severe adverse drug reactions (ADRs). Formation of reactive intermediates by cytochrome P450s (CYPs) has been proposed as a possible explanation for these ADRs. Moreover, a protective role for human glutathione S-transferases (hGSTs)
Shalini Jain et al.
The Journal of clinical investigation, 123(4), 1750-1762 (2013-03-13)
Type 2 diabetes (T2D) has emerged as a major threat to human health in most parts of the world. Therapeutic strategies aimed at improving pancreatic β cell function are predicted to prove beneficial for the treatment of T2D. In the
Chao-Cheng Lin et al.
Journal of clinical psychopharmacology, 33(2), 211-214 (2013-02-21)
Clozapine is the most effective antipsychotic for patients with treatment-refractory schizophrenia, but many adverse effects are noted. Clinicians usually hesitate to switch from clozapine to other antipsychotics because of the risk of a re-emergence or worsening of the psychosis, although
Bianca A Silva et al.
Nature neuroscience, 16(12), 1731-1733 (2013-11-12)
The neural circuits mediating fear to naturalistic threats are poorly understood. We found that functionally independent populations of neurons in the ventromedial hypothalamus (VMH), a region that has been implicated in feeding, sex and aggression, are essential for predator and
Nasz zespół naukowców ma doświadczenie we wszystkich obszarach badań, w tym w naukach przyrodniczych, materiałoznawstwie, syntezie chemicznej, chromatografii, analityce i wielu innych dziedzinach.
Skontaktuj się z zespołem ds. pomocy technicznej