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765708

Sigma-Aldrich

Gold nanoparticles

15 nm diameter, OD 50, methyl terminated, PEG 5000 coated, dispersion in H2O

Synonim(y):

Gold nanoparticles OMe terminated, Au NP OMe, Gold Colloid

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About This Item

Kod UNSPSC:
12162002
NACRES:
NA.23

Materiały

PEG 5000

Poziom jakości

100

Postać

dispersion in H2O
nanoparticles

opakowanie

poly bottle of 1 mL

OD

50

średnica

15 nm

pH

6.0-8.0 (25 °C)

rozpuszczalność

water: miscible

gęstość

1.00 g/cm3

λmaks.

520 nm

grupa funkcyjna

methoxy

temp. przechowywania

2-8°C

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Opis ogólny

Gold nanoparticles (AuNPs) ranging from 2-200nm in diameter find applications in diverse fields. They show excellent biocompatibility and attractive physicochemical properties. AuNPs are shown to be highly sensitive colloidal biosensors. The poly (ethylene) glycol (PEG) coating on gold nanoparticles helps in the reduction of protein adsorption, reduces nonspecific interactions with cells and greatly improves the pharmokinetics of these nanoparticles and disables aggregation of the nanoparticles.PEG layer density depends inversely on the AuNP curvature. AuNPs coated with PEG 5000 exhibited the highest colloidal stability. The methyl group, being hydrophobic acts as a protecting shield between the gold nanoparticles and the hydrophilic outer PEG coating and also leads to a further reduction of protein adsorption and macrophage uptake by the AuNPs.

Zastosowanie

Several other specific applications have been listed below:
  • Since they adhere to cell membranes, AuNPs may find use in cellular and intracellular targeting in targeted drug delivery applications and may also used in biodistribution studies.
  • AuNPs may also be used in photothermal therapy and radiotherapy.
  • AuNPs ranging from 10 to 250 nm, were studied to have been absorbed primarily by liver and spleen, when injected intravenously in rats.Whereas, 10 nm nanoparticles were distributed more broadly into various organs.
Functionalized Particles have been extensively used to study cellular uptake of nanoparticles and targeted drug delivery.

Cechy i korzyści

PEG decreases the cytotoxicity and increases efficiency of GNPs in targeted drug delivery. PEG increases the stability of the nanoparticles and prevents agglomeration. Forms complexes easily with dyes and thiol ligands.
This page may contain text that has been machine translated.

Kod klasy składowania

12 - Non Combustible Liquids

Klasa zagrożenia wodnego (WGK)

WGK 1

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Wybierz jedną z najnowszych wersji:

Certyfikaty analizy (CoA)

Lot/Batch Number
MKCH6892
MKCG7332
MKBX4816V
MKBN9363V
MKBL7659V

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International journal of nanomedicine, 6, 2071-2081 (2011-10-07)
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Produkty

Micro- and Nanofabricated Biomaterials for the Study of Cells and Microtissues

Biomaterials science involves the design and fabrication of smart materials for studying, directing, or mimicking biology. For successful integration of biomaterials in biological research, a meaningful understanding of biological systems is required.

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