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Merck

PRKCZ

protein kinase C, zeta

Synonimy:
PKC-ZETA, PKC2
Gatunek:
Identyfikator UniProtKB:
Identyfikator genu:
  • Human(5590) Summary: Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
  • Mouse(18762) protein kinase C, zeta
  • Rat(25522) protein kinase C, zeta
  • Domestic Rabbit(100009538) protein kinase C, zeta
  • naked mole-rat(101699303) protein kinase C, zeta
  • domestic guinea pig(100734946) protein kinase C, zeta
  • cow(286877) protein kinase C, zeta
  • sheep(101122295) protein kinase C, zeta
  • Zebrafish(555737) protein kinase C, zeta
  • chicken(419399) protein kinase C, zeta
  • domestic cat(101087851) protein kinase C, zeta
  • dog(479577) protein kinase C, zeta

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Antibodies

Product Number
Opis
Reaktywność gatunkowa
Zastosowanie
Anti-PKC ζ antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
ELISA
immunofluorescence

immunohistochemistry

western blot
Anti-PRKCZ antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reaktywność gatunkowa
human, mouse
Zastosowanie
immunofluorescence
immunohistochemistry

western blot
Anti-PKC ζ Antibody, clone 1F20 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reaktywność gatunkowa
human
Zastosowanie
ELISA
affinity binding assay

western blot
Anty-fosfo-PKCzeta-T560, ,
Reaktywność gatunkowa
human
Zastosowanie
western blot
Anti-phospho-PKC ζ (pThr410) antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
ELISA
immunofluorescence

immunohistochemistry

western blot

Small Molecule - Inhibitor

Product Number
Opis
Gatunek
UCN-01, ≥97% (HPLC), powder,
Gatunek
human
GSK690693, ≥98% (HPLC),
Gatunek
human

Proteins

Product Number
Opis
Gatunek
Protein Kinase Cζ isozyme human, ≥75% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous solution,
Gatunek
human

esiRNA

Product Number
Opis
Gatunek
MISSION® esiRNA, targeting human PRKCZ,
Gatunek
human