Skip to Content
Merck
All Photos(1)

Documents

Z4277

Sigma-Aldrich

Zileuton

≥98% (HPLC)

Synonym(s):

(±)-N-hydroxy-N-(1-benzo[b]thien-2-ylethyl)urea

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C11H12N2O2S
CAS Number:
111406-87-2
Molecular Weight:
236.29
MDL number:
MFCD00866097
UNSPSC Code:
12352200
PubChem Substance ID:
329831613
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: ≥20 mg/mL at ~60 °C (warm up to 60 C for 5min)

originator

Abbott

storage temp.

room temp

SMILES string

CC(N(O)C(N)=O)c1cc2ccccc2s1

InChI

1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14)

InChI key

MWLSOWXNZPKENC-UHFFFAOYSA-N

Gene Information

human ... ALOX5(240)

Looking for similar products? Visit Product Comparison Guide

Biochem/physiol Actions

Zileuton is an anti-asthmatic, an inhibitor of 5-lipoxygenase; the initial enzyme in the biosynthesis of leukotrienes from arachidonic acid.

Features and Benefits

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Warning

Hazard Statements

H302,H361d

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Norwin Kubick et al.
Molecules (Basel, Switzerland), 25(9) (2020-05-10)
Repurposing drugs to target M1 macrophages inflammatory response in depression constitutes a bright alternative for commonly used antidepressants. Depression is a significant type of mood disorder, where patients suffer from pathological disturbances associated with a proinflammatory M1 macrophage phenotype. Presently
Kaneez Fatima et al.
Frontiers in nutrition, 9, 857256-857256 (2022-04-26)
Carvacrol, a monoterpene known for its pharmacological activities, is present in the essential oil of Origanum majorana, Origanum vulgare, Thymus vulgaris, and Lippia graveolens. It is used in food as a flavoring and preservative agent in cosmetics and medicines because
Ju Youn Lee et al.
Nature communications, 11(1), 2358-2358 (2020-05-14)
Sphingosine kinase1 (SphK1) is an acetyl-CoA dependent acetyltransferase which acts on cyclooxygenase2 (COX2) in neurons in a model of Alzheimer's disease (AD). However, the mechanism underlying this activity was unexplored. Here we show that N-acetyl sphingosine (N-AS) is first generated
M Bessadóttir et al.
Prostaglandins, leukotrienes, and essential fatty acids, 98, 39-47 (2015-05-13)
Lipoxygenases (LOXs) and their products are involved in several biological functions and have been associated with carcinogenesis. Protolichesterinic acid (PA), a lichen metabolite, inhibits 5- and 12-LOX and has anti-proliferative effects on various cancer cell lines. Here, PA was shown
Tsugunobu Andoh et al.
Journal of dermatological science, 76(3), 206-213 (2014-12-03)
Phosphodiesterase 4 (PDE4), which catalyses the conversion of cyclic adenosine 3',5'-monophosphate (cAMP) to 5'-AMP, plays a critical role in the pathogenesis of inflammatory disorders. Pruritus is the main symptom of dermatitides, such as atopic dermatitis, and is very difficult to

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service