ABT49
Anti-Dynamin-2 Antibody
serum, from rabbit
Synonym(s):
dynamin 2, dynamin II, dynamin-2
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.43
biological source
rabbit
Quality Level
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human
technique(s)
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... DNM2(1785)
General description
Dynamin-2 is a ubiquitously expressed, membrane associated protein belonging to the Dynamin protein family of GTPases, a group consisting of three isoforms with distinct tissue specificity and function. Dynamin localizes to plasma membrane-coated pits by its interactions with amphiphysin through the dynamin PRD domain. Dynamin-2 is a component in the manufacture of microtubule bundles, and is capable of both binding and hydrolyzing GTP. It is also likely to be involved in the trafficking mechanisms for vesicles, especially those pertaining to endocytosis. Defects in the expression of Dynamin-2 have been shown to cause Charcot-Marie-Tooth disease dominant intermediate type B (CMTDIB), and centronuclear myopathy autosomal dominant (ADCNM). There is also some interest in Dynamin-2 as a potential regulator for adenovirus targeting cancer therapies.
Immunogen
KLH-conjugated linear peptide corresponding to human Dynamin-2.
Application
Detect Dynamin-2 using this Anti-Dynamin-2 Antibody validated for use in WB.
Research Category
Cell Structure
Cell Structure
Research Sub Category
Cytoskeletal Signaling
Cytoskeletal Signaling
Quality
Evaluated by Western Blot in HeLa cell lysate.
Western Blot Analysis: 1:1,000 dilution of the antibody detected Dynamin-2 in 10 µg of HeLa cell lysate.
Western Blot Analysis: 1:1,000 dilution of the antibody detected Dynamin-2 in 10 µg of HeLa cell lysate.
Target description
~ 98 kDa observed
Physical form
Rabbit polyclonal serum containing 0.5% sodium azide.
Unpurified
Storage and Stability
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Analysis Note
Control
HeLa cell lysate
HeLa cell lysate
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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