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T7165

Sigma-Aldrich

Tyrphostin 23

≥98%

Sinónimos:

(3,4-Dihydroxybenzylidene)malononitrile, RG-50810

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About This Item

Fórmula empírica (notación de Hill):
C10H6N2O2
Número de CAS:
118409-57-7
Peso molecular:
186.17
MDL number:
MFCD00133899
UNSPSC Code:
12352200
PubChem Substance ID:
24278041
NACRES:
NA.77

biological source

synthetic (organic)

assay

≥98%

form

powder

potency

35 μM IC50

solubility

DMSO: soluble 50 mg/mL, clear, yellow to brownish-yellow

storage temp.

2-8°C

SMILES string

Oc1ccc(cc1O)\C=C(\C#N)C#N

InChI

1S/C10H6N2O2/c11-5-8(6-12)3-7-1-2-9(13)10(14)4-7/h1-4,13-14H

InChI key

VTJXFTPMFYAJJU-UHFFFAOYSA-N

Gene Information

human ... CDK2(1017)

Application

Tyrphostin 23 can be used as a tyrosine kinase inhibitor for studying rat ghrelin-induced MAPK stimulation in GH3 cells. Tyrphostin 23 has also been used to analyze its effects on secretoneurin (SN)-induced chemotaxis of neutrophils.

Biochem/physiol Actions

Tyrphostin 23 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain,.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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