Todas las fotos(1)

Documentos clave

Ver Toda la documentación

M2419

Midazolam maleate salt

Name: Midazolam maleate salt
Brand: SIGMA

≥98% (TLC), powder, GABAA receptor ligand

Sinónimos:

8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine maleate salt

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización

Todas las fotos(1)

About This Item

Fórmula empírica (notación de Hill):

C₁₈H₁₃ClFN₃ · C₄H₄O₄

Número de CAS:

59467-94-6

Peso molecular:

441.84

EC Number:

261-775-0

MDL number:

MFCD00941440

UNSPSC Code:

12352200

PubChem Substance ID:

24896731

NACRES:

NA.77

Productos recomendados

Slide 1 of 6

1 of 6

Supelco

L-049

Loprazolam solution

BP722

Midazolam

Y0000599

Midazolam for system suitability

Supelco

P-174

1CP-LSD (1-Cyclopropionyl lysergic acid diethylamide) solution

L0750500

Lorazepam

Sigma-Aldrich

SML1606

Oseltamivir phosphate

Nombre del producto

Midazolam maleate salt,

Quality Level

300

drug control

USDEA Schedule IV; Home Office Schedule 3; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)

originator

Roche

storage temp.

2-8°C

SMILES string

OC(=O)\C=C/C(O)=O.Cc1ncc2CN=C(c3ccccc3F)c4cc(Cl)ccc4-n12

InChI

1S/C18H13ClFN3.C4H4O4/c1-11-21-9-13-10-22-18(14-4-2-3-5-16(14)20)15-8-12(19)6-7-17(15)23(11)13;5-3(6)1-2-4(7)8/h2-9H,10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI key

XYGVIBXOJOOCFR-BTJKTKAUSA-N

Gene Information

human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879)

Biochem/physiol Actions

Sedative/Hypnotic; ligand for the GABA_A receptor benzodiazepine modulatory site; CYP3A4 substrate.

Features and Benefits

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Elija entre una de las versiones más recientes:

Certificados de análisis (COA)

Lot/Batch Number

¿No ve la versión correcta?

Si necesita una versión concreta, puede buscar un certificado específico por el número de lote.

Busque por un COA

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Midazolam produces vasodilation by mixed endothelium-dependent and -independent mechanisms.

K S Chang et al.

Anesthesia and analgesia, 78(4), 710-717 (1994-04-01)

Aortic rings were obtained from rat thoracic aorta and studied in vitro with and without functionally intact endothelium to determine whether "the mechanism" requires endothelium [or endothelium-derived relaxing factor (EDRF)]. In aortic rings precontracted with either phenylephrine (PE, 3 x

Opposite effects of midazolam and beta-carboline-3-carboxylate ethyl ester on the release of dopamine from rat nucleus accumbens measured by in vivo microdialysis.

T Murai et al.

European journal of pharmacology, 261(1-2), 65-71 (1994-08-11)

This report describes the effects of midazolam and beta-carboline-3-carboxylate ethyl ester (beta-CCE) on extracellular concentrations of dopamine in the nucleus accumbens of freely moving rats measured by in vivo microdialysis. The two compounds had opposite effects, midazolam (0.075 and 0.15

In macrophages, caspase-1 activation by SopE and the type III secretion system-1 of S. typhimurium can proceed in the absence of flagellin.

Claudia Hoffmann et al.

PloS one, 5(8), e12477-e12477 (2010-09-04)

The innate immune system is of vital importance for protection against infectious pathogens. Inflammasome mediated caspase-1 activation and subsequent release of pro-inflammatory cytokines like IL-1beta and IL-18 is an important arm of the innate immune system. Salmonella enterica subspecies 1

Online monitoring of hepatic rat metabolism by coupling a liver biochip and a mass spectrometer.

Franck Merlier et al.

The Analyst, 142(19), 3747-3757 (2017-09-12)

A microfluidic liver biochip was coupled with a mass spectrometer to detect in real time the drug metabolism of hepatocytes. The hepatocytes were cultivated in the biochip for 35 h. The biochip was placed in a small-scale incubator in which

Amplified morphogenetic and bone forming activity of amorphous versus crystalline calcium phosphate/polyphosphate.

Werner E G Müller et al.

Acta biomaterialia, 118, 233-247 (2020-10-20)

Amorphous Ca-phosphate (ACP) particles stabilized by inorganic polyphosphate (polyP) were prepared by co-precipitation of calcium and phosphate in the presence of polyP (15% [w/w]). These hybrid nanoparticles showed no signs of crystallinity according to X-ray diffraction analysis, in contrast to

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico