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Merck
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주요 문서

1000420

USP

Abacavir Related Compound A

United States Pharmacopeia (USP) Reference Standard

동의어(들):

(1S,4R)-4-[2,6-Diamino-9H-purin-9-yl]-2-cyclopentene-1-methanol

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C11H14N6O
CAS Number:
124752-25-6
Molecular Weight:
246.27
MDL number:
MFCD00869644
UNSPSC 코드:
41116107
NACRES:
NA.24

Grade

pharmaceutical primary standard

API family

abacavir

제조업체/상표

USP

응용 분야

pharmaceutical (small molecule)

형식

neat

저장 온도

2-8°C

SMILES string

[n]2(c3nc(nc(c3nc2)N)N)[C@@H]1C[C@@H](C=C1)CO

InChI

1S/C11H14N6O/c12-9-8-10(16-11(13)15-9)17(5-14-8)7-2-1-6(3-7)4-18/h1-2,5-7,18H,3-4H2,(H4,12,13,15,16)/t6-,7+/m1/s1

InChI key

ZKJUXHDSLJYKED-RQJHMYQMSA-N

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일반 설명

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

애플리케이션

Abacavir Related Compound A USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

분석 메모

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

기타 정보

Sales restrictions may apply.

관련 제품

제품 번호
설명
가격

1000485

Abacavir Related Compounds Mixture, United States Pharmacopeia (USP) Reference Standard

1000496

Abacavir Stereoisomers Mixture, United States Pharmacopeia (USP) Reference Standard

1000500

Abacavir System Suitability Mixture, United States Pharmacopeia (USP) Reference Standard

1000408

Abacavir sulfate, United States Pharmacopeia (USP) Reference Standard

1000419

Abacavir sulfate racemic, United States Pharmacopeia (USP) Reference Standard

1000441

Abacavir Related Compound B, United States Pharmacopeia (USP) Reference Standard

1000452

Abacavir Related Compound C, United States Pharmacopeia (USP) Reference Standard

PHR1256

Abacavir sulfate, Pharmaceutical Secondary Standard; Certified Reference Material

Y0001561

Abacavir sulfate, European Pharmacopoeia (EP) Reference Standard

Y0001551

Abacavir for system suitability, European Pharmacopoeia (EP) Reference Standard

Y0001552

Abacavir for peak identification, European Pharmacopoeia (EP) Reference Standard

1000437

Abacavir Related Compound D, United States Pharmacopeia (USP) Reference Standard

BP1112

Abacavir sulfate, British Pharmacopoeia (BP) Reference Standard

BP1113

Abacavir impurity standard, British Pharmacopoeia (BP) Reference Standard

BP1114

Abacavir Impurity 1, British Pharmacopoeia (BP) Reference Standard

PHR2074

Abacavir Impurity F, pharmaceutical secondary standard, certified reference material

픽토그램

Corrosion
GHS05

신호어

Danger

유해 및 위험 성명서

H318

예방조치 성명서

P280 - P305 + P351 + P338

Hazard Classifications

Eye Dam. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

C L Zimmerman et al.
Drug metabolism and disposition: the biological fate of chemicals, 28(6), 672-679 (2000-05-23)
A CBV [(-)-carbovir, (-)-carbocyclic 2',3'-didehydro-2', 3'-dideoxyguanosine] prodrug, 6AC [(-)-6-aminocarbovir, (-)-carbocyclic 2',3'-didehydro-2', 3'-dideoxy-6-deoxy-6-aminoguanosine], was previously evaluated in rats, and it exhibited superiority to the parent drug in increasing systemic and central nervous system exposure to CBV. The gut wall was determined
R L Yeager et al.
Drug metabolism and disposition: the biological fate of chemicals, 19(2), 462-466 (1991-03-01)
The potential for the metabolic conversion of (-)-6-aminocarbovir to (-)-carbovir, a potent reverse transcriptase inhibitor effective against human immunodeficiency virus, has been examined in male Sprague-Dawley rats. Plasma (-)-6-aminocarbovir concentrations declined rapidly in a biphasic manner following an iv bolus
Y Wen et al.
Drug metabolism and disposition: the biological fate of chemicals, 27(1), 113-121 (1999-01-12)
Several in vitro and in situ approaches were used to determine the dominant presystemic activation site for (-)-6-aminocarbovir, (-)-carbocyclic 2',3'-didehydro-2', 3'-dideoxy-6-deoxy-6-aminoguanosine (6AC) conversion in rats. The in vitro disappearance half-lives (mean +/- S.D.) in the cytosolic fractions obtained from homogenates
Lack of effect of catheterization on the pharmacokinetics of (-)-carbovir in rats.
C L Zimmerman et al.
Pharmaceutical research, 13(9), 1417-1418 (1996-09-01)
C L Zimmerman et al.
Drug metabolism and disposition: the biological fate of chemicals, 20(1), 47-51 (1992-01-01)
The recently synthesized carbocyclic 2',3'-didehydro-2',3'-dideoxy-6-deoxy-6-amino-guanosine [(-)6AC] was evaluated as a prodrug for carbovir, carbocyclic 2',3'-didehydro-2',3'-dideoxyguanosine [(-)CBV] in seven male Sprague-Dawley rats. A randomized three-way cross-over design was used. Rats were assigned to receive the following treatments: a 20 mg/kg (-)6AC
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관련 콘텐츠

Small Molecule HPLC

Small molecules are ions and compounds of molecular weight typically less than 900 daltons. These compounds can be effectively separated and analyzed by HPLC, UHPLC and LC-MS using mainly silica particles or monolithic stationary phases with a broad range of column chemistries (modifications).

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