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Merck
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Key Documents

추가 자료

X4879

Sigma-Aldrich

Xaliproden hydrochloride

≥97% (HPLC), solid

동의어(들):

1,2,3,6-Tetrahydro-1-[2-(2-naphthalenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]pyridine hydrochloride, SR-57746A

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About This Item

실험식(Hill 표기법):
C24H22F3N · HCl
CAS Number:
90494-79-4
Molecular Weight:
417.89
MDL number:
MFCD00896209
UNSPSC 코드:
12352200
PubChem Substance ID:
329830807
NACRES:
NA.77

Quality Level

100

분석

≥97% (HPLC)

형태

solid

색상

white to off-white

solubility

DMSO: ≥5 mg/mL

주관자

Sanofi Aventis

저장 온도

2-8°C

SMILES string

Cl.FC(F)(F)c1cccc(c1)C2=CCN(CCc3ccc4ccccc4c3)CC2

InChI

1S/C24H22F3N.ClH/c25-24(26,27)23-7-3-6-22(17-23)20-11-14-28(15-12-20)13-10-18-8-9-19-4-1-2-5-21(19)16-18;/h1-9,11,16-17H,10,12-15H2;1H

InChI key

WVHBEIJGAINUBW-UHFFFAOYSA-N

유전자 정보

human ... HTR1A(3350)

생화학적/생리학적 작용

5-HT1A serotonin receptor agonist; neuroprotectant

특징 및 장점

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

픽토그램

Exclamation mark
GHS07

신호어

Warning

유해 및 위험 성명서

H302

예방조치 성명서

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

Marc Porzner et al.
Expert opinion on investigational drugs, 18(11), 1765-1772 (2009-10-10)
Neurodegenerative disorders such as Alzheimer's disease or amyotrophic lateral sclerosis as well as peripheral neuropathies are difficult to treat due to a limited range of effective drugs. Neurotrophic growth factors promote neuronal survival and differentiation and could hence be interesting
G S Ruigt et al.
Neuroscience letters, 203(1), 9-12 (1996-01-12)
A co-culture system of intact rat dorsal root ganglia (DRG) with Schwann cells was used to evaluate the potential neurotrophic activity of SR 57746A. Neuritogenesis from DRG was measured with an image analysis system following exposure to different concentrations of
A Appert-Collin et al.
International journal of immunopathology and pharmacology, 18(2), 233-244 (2005-05-13)
Neurotrophic growth factors are involved in cell survival. However, natural growth factors have a very limited therapeutic use because of their short half-life. In the present study, we investigated the mechanism of action of a non-peptidic neurotrophic drug, Xaliproden, a
Xaliproden lessens oxaliplatin-mediated neuropathy.
Ed Susman
The Lancet. Oncology, 7(4), 288-288 (2006-04-08)
J Fournier et al.
The Journal of pharmacy and pharmacology, 50(3), 323-327 (1998-05-26)
SR 57746A (1-(2beta-naphthylethyl)-4-(3-trifluoromethylphenyl)-1,2,5,6 -tetrahydropyridine hydrochloride) is a neuroprotective compound which potentiates nerve-growth factor (NGF)-induced differentiation in PC12 cells. We have evaluated the interaction of SR 57746A with the other members of the neurotrophin family in this cell-line. In contrast with
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문서

Serotonin Receptors

Sigma-Aldrich offers many products related to serotonin receptors for your research needs.

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