W1628

Wortmannin

from Penicillium funiculosum, ≥98% (HPLC and TLC)

• 동의어(들): KY 12420
• 실험식(Hill 표기법): C₂₃H₂₄O₈
• CAS Number: 19545-26-7
• Molecular Weight: 428.43
• Beilstein: 67676
• MDL number: MFCD00133927
• UNSPSC 코드: 12352207
• PubChem Substance ID: 24278777
• NACRES: NA.77

속성

• 생물학적 소스: Penicillium funiculosum
• Quality Level: 300
• 분석: ≥98% (HPLC and TLC)
• 형태: powder
• 색상: off-white
• solubility: DMSO: soluble; H₂O: unstable
• 저장 온도: 2-8°C
• SMILES string: [H][C@@]12CCC(=O)[C@@]1(C)C[C@@H](OC(C)=O)C3=C2C(=O)c4occ5C(=O)O[C@H](COC)[C@@]3(C)c45
• InChI: 1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1
• InChI key: QDLHCMPXEPAAMD-QAIWCSMKSA-N
• 유전자 정보: human ... PIK3CD(5293) , PIK3CG(5294) , PIK3R1(5295)

설명

생화학적/생리학적 작용

Wortmannin is a potent and specific phosphatidylinositol 3-kinase (PI3-K) inhibitor with an IC₅₀ of 2-4 nM. Inhibition of PI3-K/Akt signal transduction cascade enhances the apoptotic effects of radiation or serum withdrawal and blocks the antiapoptotic effect of cytokines. Inhibition of PI3-K by wortmannin also blocks many of the short-term metabolic effects induced by insulin receptor activation.

특징 및 장점

This compound is a featured product for Cyclic Nucleotide and Kinase Phosphatase Biology research. Discover more featured Cyclic Nucleotide and Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the G Proteins (Heterotrimeric) and Phosphoinositide Kinases pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H300 + H310 + H330
• 예방조치 성명서: P260 - P262 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310
• Hazard Classifications: Acute Tox. 1 Inhalation - Acute Tox. 1 Oral - Acute Tox. 2 Dermal
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges