V8879

Vincristine sulfate salt

95.0-105.0% (HPLC), powder or crystals

• 동의어(들): 22-Oxovincaleukoblastine sulfate salt, Leurocristine sulfate salt, VCR
• 실험식(Hill 표기법): C₄₆H₅₆N₄O₁₀ · H₂SO₄
• CAS Number: 2068-78-2
• Molecular Weight: 923.04
• Beilstein: 3924631
• EC Number: 218-190-0
• MDL number: MFCD00084729
• UNSPSC 코드: 51111767
• PubChem Substance ID: 57654729
• NACRES: NA.85

속성

• 생물학적 소스: Streptomyces roseosporus
• 분석: 95.0-105.0% (HPLC)
• 양식: powder or crystals
• 저장 조건: (Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)
• 색상: white to light yellow
• 항생제 활성 스펙트럼: neoplastics
• 동작 모드: protein synthesis | interferes
• 저장 온도: −20°C
• SMILES string: OS(O)(=O)=O.CC[C@]1(O)CC2CN(CCc3c([nH]c4ccccc34)[C@@](C2)(C(=O)OC)c5cc6c(cc5OC)N(C=O)C7[C@](O)([C@H](OC(C)=O)[C@]8(CC)C=CCN9CC[C@]67C89)C(=O)OC)C1
• InChI: 1S/C46H56N4O10.H2O4S/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6;1-5(2,3)4/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3;(H2,1,2,3,4)/t28-,37-,38+,39+,42-,43+,44+,45-,46-;/m0./s1
• InChI key: AQTQHPDCURKLKT-PNYVAJAMSA-N

설명

애플리케이션

Vincristine is an antitumor alkaloid isolated from Vinca Rosea. It is used to treat acute leukaemia, malignant lymphoma, Hodgkin′s disease, acute erythraemia, acute panmyelosis, breast cancer, Kaposi′s sarcoma and testicular cancer. Vincristine is widely used in cancer research. It is used to study multi-drug resistance. It is used to inhibit cell cycle progression at M-phase and to inhibit monoamine oxidase (MAO) .

생화학적/생리학적 작용

Vincristine is a plant alkaloid that inhibits microtubule assembly by binding tubulin and inducing coiled spiral aggregate formation. It arrests cell cycle in G2/M-phase by blocking mitotic spindle formation. Vincristine triggers Raf-1 activation, phosphorylation of bcl-2-family proteins, induction of p53 expression, and apoptosis in several tumor cell lines. It inhibits VEGF production in leukemia cell lines. It is a substrate for Pgp and CYP3A4. MRP1 transports vincristine in an ATP- and GSH-dependent manner. Vincristine has some immunosuppressant effect. Vincristine may also interfere with amino acid, cyclic AMP, and glutathione metabolism, calmodulin-dependent Ca2+-transport, cellular respiration, and nucleic acid and lipid biosynthesis.

분석 메모

Freely soluble in water, Soluble in methanol, slightly soluble in ethanol

기타 정보

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

안전성 정보

• 픽토그램: GHS06,GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H300,H341,H361fd
• 예방조치 성명서: P202 - P264 - P270 - P280 - P301 + P310 - P405
• Hazard Classifications: Acute Tox. 2 Oral - Muta. 2 - Repr. 2
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable