V4253

[β-Mercapto-β,β-cyclopentamethylenepropionyl¹, O-Et-Tyr², Val⁴, Arg⁸]-Vasopressin

≥97% (HPLC)

• 실험식(Hill 표기법): C₅₃H₇₅N₁₃O₁₁S₂
• CAS Number: 77453-01-1
• Molecular Weight: 1134.37
• MDL number: MFCD00076752
• UNSPSC 코드: 51111800
• PubChem Substance ID: 329829049
• NACRES: NA.32
• 생물학적 소스: synthetic (organic)
• 양식: powder
• 분석: ≥97% (HPLC)

속성

• 생물학적 소스: synthetic (organic)
• Quality Level: 200
• 분석: ≥97% (HPLC)
• 양식: powder
• solubility: water: 1 mg/mL, clear, colorless
• 배송 상태: ambient
• 저장 온도: −20°C
• SMILES string: CCOc1ccc(C[C@@H]2NC(=O)CC3(CCCCC3)SSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc4ccccc4)NC2=O)C(C)C)C(=O)N5CCC[C@H]5C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O)cc1
• InChI: 1S/C53H77N13O11S2/c1-4-77-34-19-17-33(18-20-34)26-36-46(71)62-37(25-32-13-7-5-8-14-32)48(73)65-44(31(2)3)50(75)63-38(27-41(54)67)47(72)64-39(30-78-79-53(28-43(69)60-36)21-9-6-10-22-53)51(76)66-24-12-16-40(66)49(74)61-35(15-11-23-58-52(56)57)45(70)59-29-42(55)68/h5,7-8,13-14,17-20,31,35-40,44H,4,6,9-12,15-16,21-30H2,1-3H3,(H2,54,67)(H2,55,68)(H,59,70)(H,60,69)(H,61,74)(H,62,71)(H,63,75)(H,64,72)(H,65,73)(H4,56,57,58)/t35-,36-,37-,38-,39-,40-,44-/m0/s1
• InChI key: SDFJYGJKEXYVCG-ZZTMPEIHSA-N
• 유전자 정보: human ... AVPR1A(552) , AVPR2(554) , OXT(5020) , OXTR(5021) ; mouse ... AVPR1A(54140) , AVPR2(12000) ; rat ... AVPR1A(25107) , AVPR2(25108) , OXT(18429) , OXTR(18430)

설명

Amino Acid Sequence

(1-Mercaptocyclohexyl)acetyl-Tyr(O-Ethyl)-Phe-Val-Asn-Cys-Pro-Arg-Gly-NH2 [Disulfide Bridge: 1-6]

애플리케이션

[Beta-Mercapto-beta, beta-cyclopentamethylenepropionyl¹, O-Et-Tyr², Val⁴, Arg⁸]-Vasopressin is a potent V1a and V2 vasopressin receptor anatgonist, used for examining the impact of vasopressin V1receptor blockade in rats.The product was also be used for visualizing cell surface V1a receptors in rat hepatocytes by using high-affinity fluorescent linear antagonist, Rhm8 -PVA.

생화학적/생리학적 작용

Vasopressin also known as antidiuretic hormone (ADH) or argipressin can stimulate three acid-base transporters and hence increases the capability of the cell to regulate pHi.ADH can induce reversible translocation of aquaporin-CD water channels from intracellular vesicles to apical plasma membrane, which in turn increases the water permeability of collecting duct cells.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H332
• 예방조치 성명서: P261 - P271 - P304 + P340 + P312
• Hazard Classifications: Acute Tox. 4 Inhalation
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves