T9772

Triazolam

• 동의어(들): 8-Chloro-6-[2-chlorophenyl]-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
• 실험식(Hill 표기법): C₁₇H₁₂Cl₂N₄
• CAS Number: 28911-01-5
• Molecular Weight: 343.21
• EC Number: 249-307-3
• MDL number: MFCD00079623
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24900602
• NACRES: NA.77

속성

• 약물 제어: USDEA Schedule IV; Home Office Schedule 4.1; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)
• solubility: 0.1 M HCl: soluble 1 g in 600 mL solvent; chloroform: soluble 1 g in 25 mL solvent; ethanol: soluble 1 g in 1000 mL solvent; DMSO: soluble 5.4 mg/mL; dichloromethane: 50 mg/mL, clear, colorless to faintly yellow; methanol: soluble 8.8 mg/mL; H₂O: insoluble; diethyl ether: insoluble
• 주관자: Johnson & Johnson
• SMILES string: ClC1=CC=CC=C1C2=NCC3=NN=C(C)N3C4=CC=C(Cl)C=C42
• InChI: 1S/C17H12Cl2N4/c1-10-21-22-16-9-20-17(12-4-2-3-5-14(12)19)13-8-11(18)6-7-15(13)23(10)16/h2-8H,9H2,1H3
• InChI key: JOFWLTCLBGQGBO-UHFFFAOYSA-N
• 유전자 정보: human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879)

설명

애플리케이션

Triazolam has been used to define nonspecific binding in radioligand binding assays. Triazolam has also been used to study the effects of reducing mPer1 mRNA levels in mouse cerbellum.

생화학적/생리학적 작용

Anxiolytic; ligand for the GABA_A receptor benzodiazepine modulatory site.

특징 및 장점

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

제조 메모

Triazolam is soluble in dichloromethane at 50 mg/ml, with heat as needed, yielding a clear, colorless to faint yellow solution. Furthermore, 1g of triazolam is soluble in 25 mL chloroform, 1000 mL ethanol, and 600 mL 0.1 M HCl. It is also soluble in DMSO (5.4 mg/ml) and methanol (8.8 mg/ml). However, it is insoluble in water and in ether.

안전성 정보

• 픽토그램: GHS08
• 신호어: Warning
• 유해 및 위험 성명서: H361fd
• 예방조치 성명서: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)