모든 사진(1)

주요 문서

모든 문서 보기

T9576

Picropodophyllotoxin

Name: Picropodophyllotoxin
Brand: SIGMA

≥96% (HPLC), powder

동의어(들):

(5R,5aS,8aR,9R)-9-Hydroxy-5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, NSC 36407, PPP, Picropodophyllin

로그인조직 및 계약 가격 보기

모든 사진(1)

About This Item

실험식(Hill 표기법):

C₂₂H₂₂O₈

CAS Number:

477-47-4

Molecular Weight:

414.41

MDL number:

MFCD01742647

UNSPSC 코드:

12352200

PubChem Substance ID:

329826907

NACRES:

NA.77

추천 제품

Slide 1 of 10

1 of 10

Sigma-Aldrich

407247

IGF-1R Inhibitor, PPP

Sigma-Aldrich

T7191

Paclitaxel

Sigma-Aldrich

T6069

Thio-TEPA

Sigma-Aldrich

SML0995

GSK1838705A

Avanti

610000

Extruder Set with Holder/Heating Block

Sigma-Aldrich

SML3675

GSK1904529A

Sigma-Aldrich

R3501

Rifampicin

Sigma-Aldrich

SML2589

Dasatinib

Sigma-Aldrich

PZ0191

Crizotinib

Supelco

T6654

Ticlopidine hydrochloride

분석

≥96% (HPLC)

양식

powder

색상

white

solubility

DMSO: >5 mg/mL

저장 온도

2-8°C

SMILES string

COc1cc(cc(OC)c1OC)[C@H]2C3C(COC3=O)[C@@H](O)c4cc5OCOc5cc24

InChI

1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19+,20-/m0/s1

InChI key

YJGVMLPVUAXIQN-HAEOHBJNSA-N

유전자 정보

human ... IGF1R(3480)

생화학적/생리학적 작용

Picropodophyllotoxin (PPP), an epimer of podophyllotoxin (PPT), has been reported to target insulin-like growth factor-I receptor (IGF-IR) and mediate anticancer functions. However, a study in 2007, has reported that PPP can induce G2-M cell cycle arrest even in IGF-IR deficient cells. Hence, the role of PPP in IGF-IR-mediated anticancer functions is debatable.

Picropodophyllotoxin is an insulin-like growth factor-I (IGF-I) receptor kinase inhibitor.

특징 및 장점

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the InsR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

품질

May contain 2-3% ethanol (w/w)

제조 메모

Picropodophyllotoxin is soluble in DMSO at a concentration that is greater than 5 mg/ml.

픽토그램

GHS06

신호어

Danger

유해 및 위험 성명서

H301,H312,H315,H319,H335

예방조치 성명서

P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

표적 기관

Respiratory system

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number

적합한 버전을 찾을 수 없으신가요?

특정 버전이 필요한 경우 로트 번호나 배치 번호로 특정 인증서를 찾을 수 있습니다.

COA 검색

이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

이미 열람한 고객

Slide 1 of 1

1 of 1

Sigma-Aldrich

I3769

Insulin-like Growth Factor-I human

Declining vulnerability to river floods and the global benefits of adaptation.

Brenden Jongman et al.

Proceedings of the National Academy of Sciences of the United States of America, 112(18), E2271-E2280 (2015-04-23)

The global impacts of river floods are substantial and rising. Effective adaptation to the increasing risks requires an in-depth understanding of the physical and socioeconomic drivers of risk. Whereas the modeling of flood hazard and exposure has improved greatly, compelling

IGF-1 receptor tyrosine kinase inhibition by the cyclolignan PPP induces G2/M-phase accumulation and apoptosis in multiple myeloma cells.

Thomas Strömberg et al.

Blood, 107(2), 669-678 (2005-09-17)

Emerging evidence suggests the insulin-like growth factor-1 receptor (IGF-1R) to be an important mediator of tumor-cell survival and resistance to cytotoxic therapy in multiple myeloma (MM). Recently, members of the cyclolignan family have been shown to selectively inhibit the receptor

Patterns in the relationship between life expectancy and gross domestic product in Russia in 2005-15: a cross-sectional analysis.

Vladimir M Shkolnikov et al.

The Lancet. Public health, 4(4), e181-e188 (2019-04-08)

Since 2005, Russia has made substantial progress, experiencing an almost doubling of per-capita gross domestic product by purchasing power parity (GDP [PPP]) to US$24 800 and witnessing a 6-year increase in life expectancy, reaching 71·4 years by 2015. Even greater gains

Insulin-like growth factor 1 receptor regulates hypothermia during calorie restriction.

Rigo Cintron-Colon et al.

Proceedings of the National Academy of Sciences of the United States of America, 114(36), 9731-9736 (2017-08-23)

When food resources are scarce, endothermic animals can lower core body temperature (T

The insulin-like growth factor-I receptor inhibitor picropodophyllin causes tumor regression and attenuates mechanisms involved in invasion of uveal melanoma cells.

Ada Girnita et al.

Clinical cancer research : an official journal of the American Association for Cancer Research, 12(4), 1383-1391 (2006-02-21)

Uveal melanoma has a high mortality rate due to a high incidence of metastasis (up to 50%), which preferentially occurs in the liver. Conventional chemotherapy, being the only therapeutic option today against metastatic uveal melanoma, has not proved to be

모든 관련된 서류 보기

문서

InsR

We offers many products related to InsR for your research needs.

주요 문서

Picropodophyllotoxin

≥96% (HPLC), powder

About This Item

추천 제품

속성

분석

양식

색상

solubility

저장 온도

SMILES string

InChI

InChI key

유전자 정보

설명

생화학적/생리학적 작용

특징 및 장점

품질

제조 메모

안전성 정보

픽토그램

신호어

유해 및 위험 성명서

예방조치 성명서

Hazard Classifications

표적 기관

Storage Class Code

WGK

Flash Point (°F)

Flash Point (°C)

개인 보호 장비

문서

시험 성적서(COA)

이 제품을 이미 가지고 계십니까?

이미 열람한 고객

관련 참고 논문

관련 참고 프로토콜

문서

관련 콘텐츠

기술 서비스