T6031

DL-Thiorphan

≥98% (TLC)

• 동의어(들): (±)-N-(3-Mercapto-2-benzylpropionyl)glycine, DL-3-Mercapto-2-benzylpropanoylglycine
• 실험식(Hill 표기법): C₁₂H₁₅NO₃S
• CAS Number: 76721-89-6
• Molecular Weight: 253.32
• Beilstein: 4872101
• MDL number: MFCD00058435
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278747
• NACRES: NA.77

속성

• Quality Level: 200
• 분석: ≥98% (TLC)
• 양식: powder
• mp: 138 °C
• solubility: ethanol: soluble 49.00-51.00 mg/mL, clear, colorless
• SMILES string: OC(=O)CNC(=O)C(CS)Cc1ccccc1
• InChI: 1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15)
• InChI key: LJJKNPQAGWVLDQ-UHFFFAOYSA-N
• 유전자 정보: human ... ACE(1636) , ECE1(1889) ; rat ... Ace(24310) , Mme(24590)

설명

일반 설명

Thiorphan, also called DL-mercapto-2-benzylpropanoyl-glycine is a specific and potent inhibitor of enkephalinase in nanomolar concentrations. It is an inhibitor of neutral endopeptidase. It interacts with cluster of differentiation 10 (CD10) in bone marrow cells and may modulate hematopoiesis. Thiorphan is a safe drugprescribed for diarrhea. It prevents cortical damage in newborn mice and is a potent agent for treating cerebral palsy.(CP)

애플리케이션

DL-Thiorphan has been used to evaluate the activity of NEP-dependent neutral endopeptidase. DL-Thiorphan has also been used for determining NEP enzymatic activity using fluorimetric assays.

생화학적/생리학적 작용

Enkephalinase inhibitor.

특징 및 장점

This compound is featured on the Neuropeptidases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

제조 메모

DL-Thiorphan is soluble in ethanol at 49.00 - 51.00 mg/ml and yields a clear, colorless solution.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)