T3652

Triptolide

from Tripterygium wilfordii, ≥98% (HPLC), solid, immunosuppressant

• 동의어(들): PG 490
• 실험식(Hill 표기법): C₂₀H₂₄O₆
• CAS Number: 38748-32-2
• Molecular Weight: 360.40
• MDL number: MFCD00210565
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24900156
• NACRES: NA.77

속성

• product name: Triptolide, from Tripterygium wilfordii, ≥98% (HPLC), solid
• 생물학적 소스: Tripterygium wilfordii
• 분석: ≥98% (HPLC)
• 형태: solid
• 색상: white to off-white
• solubility: DMSO: soluble
• 저장 온도: 2-8°C
• SMILES string: O=C1OCC2=C1CC[C@]3(C)[C@]4(O5)[C@@H]5[C@H]6[C@@](O6)(C(C)C)[C@@H](O)[C@]4(O7)[C@@H]7C[C@]32[H]
• InChI: 1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11?,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1
• InChI key: DFBIRQPKNDILPW-KTGKZQHOSA-N

설명

애플리케이션

Triptolide has been used as a NF-κB inhibitor to study the inhibition of cell invasion and angiogenesis in human thyroid cancer cells⁶. Triptolide has also been used to study its apoptotic effects in anaplastic thyroid cancer cells⁷.

생화학적/생리학적 작용

Triptolide is a diterpene triepoxide, the principal active ingredient in extracts from the Chinese herb Tripterygium wilfordii hook (TwHF). It is a potent immunosuppressant and anti-inflammatory. Triptolide has been shown to inhibit the expression of IL-2 in activated T cells at the level of purine-box/nuclear factor and NF-κB mediated transcription activation. It synergizes with cyclosporin A in promoting graft survival in animal models and in suppression of graft versus host disease in allogeneic bone marrow transplants. In addition, it induces apoptosis in tumor cells and potentiates tumor necrosis factor (TNF_α) induction of apoptosis in part through the suppression of c-IAP₂ and c-IAP₁ induction.

제조 메모

Triptolide is soluble in DMSO. The stock solution should be stored in DMSO at -20 deg C after reconstitution.

안전성 정보

• 픽토그램: GHS06,GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H300 + H330,H361f
• 예방조치 성명서: P202 - P260 - P264 - P270 - P271 - P304 + P340 + P310
• Hazard Classifications: Acute Tox. 1 Inhalation - Acute Tox. 1 Oral - Repr. 2
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)