T3450

Thiolutin

from Streptomyces luteosporeus, ≥95% (HPLC)

• 동의어(들): Farcinicin, N-(4,5-Dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl), Propiopyvothine
• 실험식(Hill 표기법): C₈H₈N₂O₂S₂
• CAS Number: 87-11-6
• Molecular Weight: 228.29
• MDL number: MFCD07370147
• UNSPSC 코드: 12352105
• PubChem Substance ID: 329826766
• NACRES: NA.77

속성

• 생물학적 소스: Streptomyces luteosporeus
• Quality Level: 200
• 분석: ≥95% (HPLC)
• 형태: solid
• solubility: DMSO: 0.90 - 1.10 mg/ml, clear, yellow
• 항생제 활성 스펙트럼: fungi
• 동작 모드: enzyme | inhibits
• 배송 상태: wet ice
• 저장 온도: −20°C
• SMILES string: CCC(=O)NC1=C2SSC=C2N(C)C1=O
• InChI: 1S/C9H10N2O2S2/c1-3-6(12)10-7-8-5(4-14-15-8)11(2)9(7)13/h4H,3H2,1-2H3,(H,10,12)
• InChI key: UGZYFXMSMFMTSM-UHFFFAOYSA-N

설명

애플리케이션

Thiolutin has been used as a polymerase II inhibitor:

• to study its effects on yeast cells to calculate transcript half-life
• to study its effects on transcription during germination in budding yeast
• to study its effects on cell adhesion in zebrafish

생화학적/생리학적 작용

Sulfur-containing antibiotic, which is a potent inhibitor of bacterial and yeast RNA polymerases. It was found to inhibit in vitro RNA synthesis directed by all three yeast RNA polymerases (I, II, and III). Thiolutin is also an inhibitor of mannan and glucan formation in Saccharomyces cerevisiae and used for the analysis of mRNA stability. Studies have shown that thiolutin inhibits adhesion of human umbilical vein endothelial cells (HUVECs) to vitronectin and thus suppresses tumor cell-induced angiogenesis in vivo.

제조 메모

Thiolutin dissolves in DMSO at 0.90 - 1.10 mg/ml to yield a clear, yellow solution.

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H300
• 예방조치 성명서: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 2 Oral
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges