SRP6362

IL13RA2 human

recombinant, expressed in E. coli, ≥85% (SDS-PAGE)

• 동의어(들): CD213A2, CT19, IL-13R, IL13BP, Interleukin-13 receptor subunit alpha-2 precursor
• UNSPSC 코드: 12352200
• NACRES: NA.32

속성

• 생물학적 소스: human
• 재조합: expressed in E. coli
• 분석: ≥85% (SDS-PAGE)
• 양식: liquid
• 분자량: 39.5 kDa (340 aa, 27-343 aa + His Tag)
• 포장: pkg of 100 μg
• 농도: 1 mg/mL
• UniProt 수납 번호: Q14627
• 배송 상태: dry ice
• 저장 온도: −70°C
• 유전자 정보: human ... IL13RA2(3598)

설명

일반 설명

IL13Rα2 (interleukin 13 receptor subunit alpha 2) is a 42 kDa monomeric high affinity IL13 receptor. This gene is located on human chromosome Xq.

IL13RA2 is closely related to Il13RA1, a subunit of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. Recombinant human IL13RA2 protein, fused to His-tag at N-terminus, was expressed in E.coli.

생화학적/생리학적 작용

IL-13Rα2 (interleukin 13 receptor subunit α 2) induces the progression, migration and invasion of glioma cells. It has the ability to initiate Scr (selective catalytic reduction), phosphatidylinositol 3 kinase (PI3K), Akt (signaling pathway) and mTOR (mammalian target of rapamycin). IL-13Rα2 chain plays a key role in IL-13 cytotoxin-mediated therapy. It is expressed at high levels in several human tumors such as oral squamous cell carcinoma, breast cancer, clear cell renal cell carcinoma, hepatic cell cancer, ovarian cancer and colorectal cancer.

물리적 형태

1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea and 10% glycerol.

안전성 정보

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable