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Merck
모든 사진(1)

Key Documents

SRP6314

Sigma-Aldrich

Alpha 2 Macroglobulin from human plasma

≥95% (SDS-PAGE)

동의어(들):

A2M, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5, CPAMD5, FWP007

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About This Item

UNSPSC 코드:
12352202
NACRES:
NA.32

생물학적 소스

human

분석

≥95% (SDS-PAGE)

형태

lyophilized

분자량

725 kDa (Homotetramer Subunit size: 180 kDa)

포장

pkg of 1 mg

UniProt 수납 번호

배송 상태

wet ice

저장 온도

−20°C

유전자 정보

human ... A2M(2)

일반 설명

α 2 macroglobulin (A2M) is a major serum protein found at concentrations of 240 mg/100 mL in men and 290 mg/100 mL in women. It is produced by the liver, and is a major component of the α-2 band in protein electrophoresis. It has a molecular weight of 800,000 Da.

생화학적/생리학적 작용

α 2 macroglobulin (A2M) functions as a broad-spectrum protease-binding protein. It is a large plasma glycoprotein that has long been known as an irreversible inhibitor of a variety of proteinases. More recently, it has been reported that numerous growth factors, cytokines and hormones bind to α 2M through diverse mechanisms. A2M is also produced in the brain where it binds multiple extracellular ligands and is internalized by neurons and astrocytes. In the brain of Alzheimer′s disease (AD) patients, A2M has been localized to diffuse amyloid plaques. A2M also binds soluble β-amyloid, of which it mediates degradation. Clinically, levels are increased in liver cirrhosis, nephrotic syndrome, diabetes, and severe burn cases.

물리적 형태

Lyophilized from 30 mM Na Phosphate, pH 7.0, with glycine as a stabilizer.

재구성

In water or aqueous buffer

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서 라이브러리 방문

The interaction of alpha 2-macroglobulin with proteinases. Characteristics and specificity of the reaction, and a hypothesis concerning its molecular mechanism.
Barrett AJ and Starkey PM
The Biochemical Journal, 133, 709-724 (1973)
Interleukin-6 and alpha-2-macroglobulin indicate an acute-phase state in Alzheimer's disease cortices.
Bauer J
Febs Letters, 285, 111-114 (1991)
Jennifer L Robinson et al.
Scientific reports, 8(1), 8527-8527 (2018-06-06)
Temporomandibular joint degenerative disease (TMJ-DD) is a chronic form of TMJ disorder that specifically afflicts people over the age of 40 and targets women at a higher rate than men. Prevalence of TMJ-DD in this population suggests that estrogen loss

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