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Merck
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Key Documents

H3536

Sigma-Aldrich

Haptoglobin from pooled human plasma

≥95% (SDS-PAGE), lyophilized powder

동의어(들):

Haptoglobin from human plasma

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About This Item

CAS Number:
MDL number:
UNSPSC 코드:
12352202
NACRES:
NA.61

생물학적 소스

human plasma (pooled)

Quality Level

분석

≥95% (SDS-PAGE)

형태

lyophilized powder

기술

activity assay: suitable

solubility

H2O: soluble 10 mg/mL

UniProt 수납 번호

저장 온도

−20°C

유전자 정보

human ... HP(3240)

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일반 설명

Haptoglobin is an α2-globulin found in normal plasma at a concentration of 82-236 mg/dl and accounts for 0.4-2.6% of the total plasma proteins.The monomeric form of this acute phase plasma protein is composed of four polypeptide chains: two α chains and two β chains.
Haptoglobin is an acute phase protein that scavenges hemoglobin released into the circulation. Haptoglobin, the plasma protein with highest binding affinity to hemoglobin, is mainly expressed in the liver.

애플리케이션

Haptoglobin was used to study induction of the acrosome reaction in sperm. Exposure to low temperature increases their rate of fusion with zona-free hamster oocytes.

생화학적/생리학적 작용

Functions by binding to plasma hemoglobin (from hemolysis). The complex is removed from the circulation, by binding to CD163 receptors on macrophages, to salvage iron and prevent oxidative damage.

기타 정보

Occurs as 3 major phenotypes: type 1-1, type 2-1, type 2-2.

면책조항

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서 라이브러리 방문

R Sanchez et al.
International journal of andrology, 14(6), 423-430 (1991-12-01)
The fusion rate of human sperm with zona-free hamster ova was investigated after induction of the acrosome reaction by exposure to a low temperature (4 degrees C). Sperm were collected from 14 patients, and selected by the 'swim-up' method. The
Alexey Tarasov et al.
Biosensors & bioelectronics, 79, 669-678 (2016-01-15)
Quantitative point-of-care (POC) devices are the next generation for serological disease diagnosis. Whilst pathogen serology is typically performed by centralized laboratories using Enzyme-Linked ImmunoSorbent Assay (ELISA), faster on-site diagnosis would infer improved disease management and treatment decisions. Using the model
I B Ross et al.
Journal of neurotrauma, 8(4), 229-238 (1991-01-01)
Previously in our laboratory, nimodipine was effective in reversing posttraumatic ischemia and promoting electrophysiologic recovery in a rat spinal cord injury (SCI) model. However, these beneficial effects were achieved when nimodipine was combined with adjuvant therapy to reverse posttraumatic hypotension
Naoko Osada et al.
The Journal of biological chemistry, 298(9), 102400-102400 (2022-08-22)
The N-glycans attached to proteins contain various GlcNAc branches, the aberrant formation of which correlates with various diseases. N-Acetylglucosaminyltransferase-IVa (GnT-IVa or MGAT4A) and Gnt-IVb (or MGAT4B) are isoenzymes that catalyze the formation of the β1,4-GlcNAc branch in N-glycans. However, the

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