SRP4915

Vaspin human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE), ≥90% (HPLC)

• 동의어(들): OL-64, SERPINA12, Serpin A12 precursor, Vaspin, Visceral adipose tissue- derived serine protease inhibitor, Visceral adipose-specific serpin
• UNSPSC 코드: 12352200
• NACRES: NA.32

속성

• 생물학적 소스: human
• 재조합: expressed in E. coli
• 분석: ≥90% (HPLC); ≥90% (SDS-PAGE)
• 형태: lyophilized powder
• 분자량: ~47.0 kDa
• 포장: pkg of 25 μg
• 저장 조건: avoid repeated freeze/thaw cycles
• 불순물: endotoxin, tested
• NCBI 수납 번호: Q8IW75
• 배송 상태: dry ice
• 저장 온도: −70°C
• 유전자 정보: human ... SPA12(145264)

설명

일반 설명

Vaspin (visceral adipose-specific SERPIN), a newly identified adipokine, is a member of serine protease inhibitor family. It is also known as serpin family A member 12 (SERPINA12). The gene encoding this protein is localized on human chromosome 14q32.13. Recombinant human Vaspin produced in E. coli is a single, non-glycosylated polypeptide chain containing 415 amino acids and having a molecular mass of 47kDa.

생화학적/생리학적 작용

Vaspin (visceral adipose-specific SERPIN) is also a unique insulin sensitizing adipocytokine in obesity. A recent publication indicates that induction of human vaspin mRNA expression in adipose tissue is regulated in a fat depot-specific manner and could be associated with parameters of obesity, insulin resistance, and glucose metabolism. This protein may be useful as a biomarker with patients with acute myocardial infarction. It is a ligand of the 78kDa glucose-regulated protein/murine transmembrane protein (GRP78/MTJ-1) complex and has indirect effects on endoplasmic reticulum stress-induced metabolic disorders.

물리적 형태

1 mg/ml in 20 mM Tris pH-8, 0.2 mM PMSF and 10% glycerol.

재구성

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

안전성 정보

• Storage Class Code: 13 - Non Combustible Solids
• WGK: nwg