SML3595

Riociguat

≥98% (HPLC)

• 동의어(들): BAY 63-2521, BAY 632521, Methyl [4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl]methylcarbamate, N-[4,6-Diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-N-methylcarbamic acid methyl ester
• 실험식(Hill 표기법): C₂₀H₁₉FN₈O₂
• CAS Number: 625115-55-1
• Molecular Weight: 422.42
• MDL number: MFCD19443708
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 형태: powder
• 색상: white to beige
• solubility: DMSO: 2 mg/mL, clear
• 저장 온도: -10 to -25°C
• SMILES string: NC1=NC(C2=NN(CC3=CC=CC=C3F)C4=NC=CC=C42)=NC(N)=C1N(C(OC)=O)C
• InChI: 1S/C20H19FN8O2/c1-28(20(30)31-2)15-16(22)25-18(26-17(15)23)14-12-7-5-9-24-19(12)29(27-14)10-11-6-3-4-8-13(11)21/h3-9H,10H2,1-2H3,(H4,22,23,25,26)
• InChI key: WXXSNCNJFUAIDG-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

Riociguat is a soluble guanylate cyclase stimulator in clinical trials for pulmonary hypertension. It increases cGMP production and induces pulmonary vasodilation. It has not effect on phosphodiesterases PDE1-9 and PDE11 when used a concentrations less than 3µM.

안전성 정보

• 픽토그램: GHS06,GHS08,GHS09
• 신호어: Danger
• 유해 및 위험 성명서: H301,H361d,H410
• 예방조치 성명서: P202 - P264 - P273 - P280 - P301 + P310 - P391
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Chronic 1 - Repr. 2
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable