SML2392

DREADD Agonist 21 dihydrochloride

≥98% (HPLC), powder, DREADD agonist

• 동의어(들): 11-(1-piperazinyl)-5H-Dibenzo[b,e][1,4]diazepine dihydrochloride, 11-(Piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine; 11-Piperazinyldibenzo[b,e][1,4]diazepine dihydrochloride, Compound 21 dihydrochloride
• 실험식(Hill 표기법): C₁₇H₁₈N₄ · 2HCl
• CAS Number: 56296-18-5
• Molecular Weight: 351.27
• MDL number: MFCD25121806
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• product name: DREADD Agonist 21 dihydrochloride, ≥98% (HPLC)
• 분석: ≥98% (HPLC)
• 형태: powder
• 저장 조건: desiccated
• 색상: yellow to brown
• solubility: H₂O: 2 mg/mL, clear
• 저장 온도: −20°C
• SMILES string: C1(C=CC=C2)=C2C(N3CCNCC3)=NC(C=CC=C4)=C4N1

설명

생화학적/생리학적 작용

Compound 21 is a potent designer drug with full agonist activity toward human hM3Dq (EC50 = 1.7 nM by cell-based Ca2+ mobilization assay), a human M3 muscarinic receptor (M3R)-based Gq (M3Dq) DREADD (Designer Receptors Exclusively Activated by Designer Drugs), displaying little activity toward muscarinic acetylcholine receptor M3 (30% M3 activation at 10 μM) and reduced affinity toward H1, 5HT2A, 5HT2C, α1A receptor (fold selectivity = 3.5, 40, 100, 165, respectively). Note: the DREADD hM3Dq exhibits M3 biological activity, but is insensitive to the endogenous ligand acetylcholine (ACh).

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable