추천 제품
분석
≥98% (HPLC)
양식
powder
색상
yellow to orange
solubility
DMSO: 2 mg/mL, clear (warmed)
저장 온도
−20°C
SMILES string
OC1=C2C(C=CC=C2)=C3C(N=C(C=CC=C4)C4=N3)=C1
생화학적/생리학적 작용
sAJM589 is a Myc inhibitor that disrupts the Myc-Max heterodimer with an IC50 value of 1.8 μM. sAJM589 was shown to suppress cellular proliferation in a variety of MYC-dependent cancer cell line including strong inhibition of Burkitt lymphoma Raji cell line growth. The mechanism of action of sAJM589 is thought to involve increased ubiquitination of Myc by inhibition of Max binding to Myc, leading to proteasome-mediated degradation.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Seung H Choi et al.
ACS chemical biology, 12(11), 2715-2719 (2017-10-05)
Myc plays important roles in cell cycle progression, cell growth, and stem cell self-renewal. Although dysregulation of Myc expression is a hallmark of human cancers, there is no Myc targeted therapy yet. Here, we report sAJM589, a novel small molecule
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