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Merck
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SML1723

Sigma-Aldrich

2-Amino-9H-pyrido[2-3-b]indole

≥98% (HPLC)

동의어(들):

2-Amino-α-carboline, 9H-1,9-Diazafluoren-2-amine, 9H-Pyrido[2,3-b]indol-2-amine, AαC, AaC

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C11H9N3
CAS Number:
26148-68-5
Molecular Weight:
183.21
MDL number:
MFCD00210750
UNSPSC 코드:
12352200
NACRES:
NA.77

Quality Level

100

분석

≥98% (HPLC)

양식

powder

색상

white to light brown

solubility

DMSO: 20 mg/mL, clear

저장 온도

−20°C

SMILES string

NC(C=C1)=NC2=C1C(C=CC=C3)=C3N2

InChI

1S/C11H9N3/c12-10-6-5-8-7-3-1-2-4-9(7)13-11(8)14-10/h1-6H,(H3,12,13,14)

InChI key

FJTNLJLPLJDTRM-UHFFFAOYSA-N

생화학적/생리학적 작용

AαC (2-Amino-9H-pyrido[2-3-b]indole) is a potential human carcinogen, which is generated by the combustion of tobacco, or by pyrolysis of protein.
AαC (2-Amino-9H-pyrido[2-3-b]indole) is a potential human carcinogen, which is generated by the combustion of tobacco, or by pyrolysis of protein. AαC potentially contributes to liver or digestive tract cancers. Inside body AαC is metabolized to intermediates (possibly short-lived nitrenium ion of AαC) that react with DNA.

픽토그램

Health hazard
GHS08

신호어

Danger

유해 및 위험 성명서

H340,H351

Hazard Classifications

Carc. 2 - Muta. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
027M4716V

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문서 라이브러리 방문

Khyatiben V Pathak et al.
The Journal of biological chemistry, 290(26), 16304-16318 (2015-05-09)
2-Amino-9H-pyrido[2,3-b]indole (AαC) is a carcinogenic heterocyclic aromatic amine formed during the combustion of tobacco. AαC undergoes bioactivation to form electrophilic N-oxidized metabolites that react with DNA to form adducts, which can lead to mutations. Many genotoxicants and toxic electrophiles react
Y Iwamoto et al.
Digestion, 31(1), 31-36 (1985-01-01)
The effects of antigastrin (SC-15396) on amylase release and 2-deoxyglucose uptake were studied in dispersed acini from mouse pancreas. Antigastrin at concentrations between 0.5 and 2 mM inhibited cholecystokinin (CCK)-stimulated amylase release and 2-deoxyglucose uptake in a dose-dependent fashion. Antigastrin
Gwendoline Nauwelaërs et al.
Chemical research in toxicology, 26(9), 1367-1377 (2013-08-01)
Aromatic amines and structurally related heterocyclic aromatic amines (HAAs) are produced during the combustion of tobacco or during the high-temperature cooking of meat. Exposure to some of these chemicals may contribute to the etiology of several common types of human
Mingjun Yao et al.
Journal of food protection, 365-376 (2020-01-24)
The effects of different grilling methods and tea marinades on the formation of heterocyclic amines (HCAs) and benzo[a]pyrene (BaP) in grilled chicken drumsticks were investigated. This study showed that both the grilling method and type of charcoal used in charcoal

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