SML1381

PIK-294

≥98% (HPLC)

• 동의어(들): 2-((4-Amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one, 2-[[4-Amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone, PIK294
• 실험식(Hill 표기법): C₂₈H₂₃N₇O₂
• CAS Number: 900185-02-6
• Molecular Weight: 489.53
• MDL number: MFCD17019338
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825829
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 형태: powder
• 색상: white to beige
• solubility: H₂O: 10 mg/mL, clear; DMSO: 5 mg/mL, clear (warmed)
• 저장 온도: −20°C
• SMILES string: NC1=C2C(N(CC(N3C4=C(C)C=CC=C4)=NC5=C(C(C)=CC=C5)C3=O)N=C2C6=CC(O)=CC=C6)=NC=N1
• InChI: 1S/C28H23N7O2/c1-16-7-3-4-12-21(16)35-22(32-20-11-5-8-17(2)23(20)28(35)37)14-34-27-24(26(29)30-15-31-27)25(33-34)18-9-6-10-19(36)13-18/h3-13,15,36H,14H2,1-2H3,(H2,29,30,31)
• InChI key: WFSLJOPRIJSOJR-UHFFFAOYSA-N

설명

애플리케이션

PIK-294 has been used as PI3K inhibitor in drug combination studies and their synergy quantification using the Chou-Talalay method.

생화학적/생리학적 작용

PIK-294 is a highly selective inihibitor of the phosphoinositide 3-kinase (PI3K) p110δ with an IC₅₀ value of 10 nM compared to IC₅₀ values of 10 μM, 490 nM and 160 nM for PI3Kα/β/γ, respectively. PIK-294 has been used to help distinguish the unique roles of the various PI3-K isoforms. For example, in a study of CXCL8-induced neutrophil migration, PIK-294 inhibited both chemokinetic and chemotactic CXCL8-induced migration whereas PI3Kγ inhibitor AS-605240 markedly reduced CXCL8 induced chemokinetic migration but had no effect on CXCL8 induced chemotactic migration.

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H301
• 예방조치 성명서: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable