SML1278

Geldanamycin Ready Made Solution

1 mg/mL, from Streptomyces hygroscopicus

• 동의어(들): 2-Azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9,13-dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-, 9-carbamate (8CI)
• 실험식(Hill 표기법): C₂₉H₄₀N₂O₉
• CAS Number: 30562-34-6
• Molecular Weight: 560.64
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 생물학적 소스: Streptomyces hygroscopicus
• Quality Level: 200
• 형태: DMSO solution
• 저장 조건: protect from light
• 농도: 1 mg/mL
• 항생제 활성 스펙트럼: neoplastics
• 동작 모드: enzyme | inhibits
• 배송 상태: dry ice
• 저장 온도: −20°C
• InChI: 1S/C29H40N2O9/c1-15-11-19-25(34)20(14-21(32)27(19)39-7)31-28(35)16(2)9-8-10-22(37-5)26(40-29(30)36)18(4)13-17(3)24(33)23(12-15)38-6/h8-10,13-15,17,22-24,26,33H,11-12H2,1-7H3,(H2,30,36)(H,31,35)/b10-8-,16-9+,18-13+/t15-,17+,22+,23+,24-,26+/m1/s1
• InChI key: QTQAWLPCGQOSGP-KSRBKZBZSA-N

설명

일반 설명

Chemical structure: benzenoid

애플리케이션

Geldanamycin Ready-Made Solution has been used as a heat shock protein 90 (Hsp90) inhibitor to pre-treat proteosome holo-enzyme during proteasome assay to study the role of proteasome on fibril fragmentation.

생화학적/생리학적 작용

Geldanamycin is a benzoquinone ansamycin and is a well known tyrosine kinase inhibitor. It possesses anticancer effects and shows therapeutic effects against osteosarcoma.

Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines. Geldanamycin binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, Geldanamycin is a potent inhibitor of the nuclear hormone receptor family.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): 188.6 °F
• Flash Point (°C): 87 °C