R2146

Radicicol from Diheterospora chlamydosporia

solid

• 동의어(들): Monorden, [1aS-(1aR*,2Z,4E,14*,15aR*)]-8-Chloro-1a,14,15,15a-tetrahydro-9,11-dihydroxy-14-methyl-6H-oxireno[e][2]benzoxacyclotetradecin-6,12(7H)-dione
• 실험식(Hill 표기법): C₁₈H₁₇ClO₆
• CAS Number: 12772-57-5
• Molecular Weight: 364.78
• MDL number: MFCD06795865
• UNSPSC 코드: 51111800
• PubChem Substance ID: 24899351
• NACRES: NA.77

속성

• 형태: solid
• Quality Level: 200
• 환경친화적 대안 제품 점수: old score: 15; new score: 9; Find out more about DOZN™ Scoring
• 환경친화적 대안 제품 특성: Waste Prevention; Atom Economy; Use of Renewable Feedstocks; Learn more about the Principles of Green Chemistry.
• sustainability: Greener Alternative Product
• 색상: white to yellow-white
• solubility: ethanol: 10 mg/mL
• 항생제 활성 스펙트럼: fungi
• 환경친화적 대안 카테고리: , Re-engineered
• 동작 모드: enzyme | inhibits
• 저장 온도: −20°C
• SMILES string: C[C@@H]1C[C@H]2O[C@@H]2C=C\C=C\C(=O)Cc3c(Cl)c(O)cc(O)c3C(=O)O1
• InChI: 1S/C18H17ClO6/c1-9-6-15-14(25-15)5-3-2-4-10(20)7-11-16(18(23)24-9)12(21)8-13(22)17(11)19/h2-5,8-9,14-15,21-22H,6-7H2,1H3/b4-2+,5-3-/t9-,14-,15-/m1/s1
• InChI key: WYZWZEOGROVVHK-GTMNPGAYSA-N
• 유전자 정보: human ... HSP90AA1(3320) , SRC(6714) ; rat ... Src(83805)

설명

애플리케이션

Radicicol from Diheterospora chlamydosporia has been used as an inhibitor of heat shock protein 90 (Hsp90):

• to study its effects on lifespan extension and health in Caenorhabditis elegans
• to study its effects on protein aggregation in yeast
• to study its effects on xanthone sensitized cancer cells

생화학적/생리학적 작용

Radicicol is an antifungal macrolactone antibiotic that is found in Diheterospora chlamydosporia, Chaetomium chiversii, and Monosporium bonorden. It functions as an inhibitor of tyrosine kinase and heat shock protein 90 (Hsp90). Radicicol is involved in the suppression of transformation of various proto-oncogenes such as Ras, Mos, and Src. It also suppresses the activity of mitogen-induced cyclooxygenase-2 (COX-2) and phosphoinositide-dependent kinase 1 (PDK1). Radicicol is involved in arresting the cell cycle at the G1-S phase. It exhibits ant-cancer and anti-angiogenic activity in vivo.

주의사항

Photosensitive

안전성 정보

• 픽토그램: GHS06,GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H301,H340,H350
• 예방조치 성명서: P202 - P264 - P280 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral - Carc. 1B - Muta. 1B
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable