SML1242

SGC707

≥98% (HPLC)

• 동의어(들): 1-Isoquinolin-6-yl-3-(2-oxo-2-pyrrolidin-1-yl-ethyl)-urea
• 실험식(Hill 표기법): C₁₆H₁₈N₄O₂
• CAS Number: 1687736-54-4
• Molecular Weight: 298.34
• UNSPSC 코드: 51111800
• PubChem Substance ID: 329825739
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to light brown
• solubility: DMSO: 20 mg/mL, clear
• 저장 온도: 2-8°C
• SMILES string: O=C(NCC(N1CCCC1)=O)NC2=CC3=CC=NC=C3C=C2
• InChI: 1S/C16H18N4O2/c21-15(20-7-1-2-8-20)11-18-16(22)19-14-4-3-13-10-17-6-5-12(13)9-14/h3-6,9-10H,1-2,7-8,11H2,(H2,18,19,22)
• InChI key: DMIDPTCQPIJYFE-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

SGC707 is a potent allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3).

SGC707 is a potent allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3). SGC707 has an IC₅₀ value of 50 nM and >100-fold selectivity over other methyltransferases and non-epigenetic targets. SGC707 binds to PRMT3 with KD of 50 nM (ITC), and inhibits histone methylation in cells with an IC₅₀ value below 1 μM. For full characterization details, please visit the SGC707 probe summary on the Structural Genomics Consortium (SGC) website.

XY1 is the negative control for the active probe, SGC707. To request a sample of the negative control from the SGC, click here.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

특징 및 장점

SGC707 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

기타 정보

SGC707 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the SGC707 probe summary on the Chemical Probes Portal website.

안전성 정보

• 픽토그램: GHS05
• 신호어: Danger
• 유해 및 위험 성명서: H318
• 예방조치 성명서: P280 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable