SML1044

Zosuquidar hydrochloride

≥98% (HPLC), powder, p-Glycoprotein inhibitor

• 동의어(들): (2R)-Anti-5-[3-[4-(10,11-difluoromethanodibenzosuber-5-yl)piperazin-1-yl]-2-hydroxypropoxy]quinoline hydrochloride, LY-335979, RS-33295-198
• 실험식(Hill 표기법): C₃₂H₃₁F₂N₃O₂ · xHCl
• CAS Number: 167354-41-8
• Molecular Weight: 527.60 (free base basis)
• UNSPSC 코드: 12161501
• PubChem Substance ID: 329825638
• NACRES: NA.77

속성

• product name: Zosuquidar hydrochloride, ≥98% (HPLC)
• 분석: ≥98% (HPLC)
• 형태: powder
• 저장 조건: desiccated
• 색상: white to beige
• solubility: H₂O: 4 mg/mL, clear (warmed)
• 저장 온도: −20°C
• SMILES string: O[C@@H](COC1=C(C=CC=N2)C2=CC=C1)CN(CC3)CCN3[C@@H]4C5=C(C=CC=C5)[C@@H]6[C@@H](C6(F)F)C7=C4C=CC=C7.Cl
• InChI: 1S/C32H31F2N3O2.ClH/c33-32(34)29-22-7-1-3-9-24(22)31(25-10-4-2-8-23(25)30(29)32)37-17-15-36(16-18-37)19-21(38)20-39-28-13-5-12-27-26(28)11-6-14-35-27;/h1-14,21,29-31,38H,15-20H2;1H/t21-,29-,30+,31-;/m1./s1
• InChI key: VQJFFWJUYDGTQZ-FCNWNIDBSA-N

설명

생화학적/생리학적 작용

Zosuqidar is a potent inhibitor of P-glycoprotein (P-gp, MDR1) a transporter protein that is a key modulator of cellular drug efflux. Zosuquidar sensitizes AML, and other cancer cell lines to cytotoxic drugs.

특징 및 장점

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안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315,H319,H335
• 예방조치 성명서: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable