SML0951

Salubrinal

≥98% (HPLC), powder, eIF2α dephosphorylation inhibitor

• 동의어(들): (2E)-3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl] 2-propenamide
• 실험식(Hill 표기법): C₂₁H₁₇Cl₃N₄OS
• CAS Number: 405060-95-9
• Molecular Weight: 479.81
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 제품명: Salubrinal, ≥98% (HPLC)
• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: , White to brown to grey
• solubility: DMSO: 20 mg/mL, clear
• 저장 온도: −20°C
• InChI: 1S/C21H17Cl3N4OS/c22-21(23,24)19(27-17(29)12-11-14-6-2-1-3-7-14)28-20(30)26-16-10-4-8-15-9-5-13-25-18(15)16/h1-13,19H,(H,27,29)(H2,26,28,30)/b12-11+
• InChI key: LCOIAYJMPKXARU-VAWYXSNFSA-N

설명

애플리케이션

Salubrinal has been used to study the effect of stress-protective genes and pathways on organism development and lifespan. It has also been used to study the therapeutic potential of salubrinal in methamphetamine induced blood–brain barrier disruption.

생화학적/생리학적 작용

Salubrinal is a selective Inhibitor of eIF2α (eukaryotic translation initiation factor 2 α-subunit) dephosphorylation, inhibiting global protein translation. Salubrinal is a specific inhibitor of ER Stress induced apoptosis.

Salubrinal maintains protein phosphorylation in order to offer protection against from the adverse effects of endoplasmic reticulum stress. Salubrinal prevents collagenase-mediated articular cartilage damage promoting downregulation of matrix metalloproteinase 13.

특징 및 장점

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안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315,H319,H335
• 예방조치 성명서: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable