추천 제품
분석
≥98% (HPLC)
형태
powder
색상
light yellow to yellow-green
solubility
DMSO: 5 mg/mL (clear solution)
저장 온도
−20°C
SMILES string
OC1=C(/C=N/S(C2=CC=CS2)(=O)=O)C3=C(C=CC=C3)C=C1
InChI
1S/C15H11NO3S2/c17-14-8-7-11-4-1-2-5-12(11)13(14)10-16-21(18,19)15-6-3-9-20-15/h1-10,17H/b16-10+
InChI key
TVIVJHZHPKNDAQ-MHWRWJLKSA-N
애플리케이션
STF-083010 has been used:
- in a study to investigate the potential anti-lipotoxic effect of nicotinamide and to elucidate underlying mechanism(s)
- as IRE1a inhibitor to study its effect on NOS 2 expression and investigate the underlying mechanisms in proinflammatory gene expression in astrocytes
- to block endogenous XBP1 cleavage for one hour prior to palmitate exposure in order to examine whether inositol?requiring enzyme 1α (IRE1α ) activation is implicated in palmitate cytotoxicity
생화학적/생리학적 작용
STF-083010 is a potent inhibitor of the ER transmembrane protein IRE1, which mediates the unfolded protein response. STF-083010 inhibits IRE1 endonuclease and mRNA splicing activity in response to endopasmic reticulum (ER) stress, but has no affect on the kinase activity of IRE1.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
이미 열람한 고객
The TLR 4-IRE 1alpha pathway activation contributes to palmitate-elicited lipotoxicity in hepatocytes
Journal of Cellular and Molecular Medicine, 22(7), 3572-3581 (2018)
Nicotinamide protects hepatocytes against palmitate-induced lipotoxicity via SIRT1-dependent autophagy induction
Nutrition Research (New York, N.Y.), 40, 40-47 (2017)
Environmental Control of Astrocyte Pathogenic Activities in CNS Inflammation
Cell, 176(3), 581-596 (2019)
Molecular pharmacology, 95(2), 183-195 (2018-11-18)
Efavirenz (EFV), a widely used antiretroviral drug, is associated with idiosyncratic hepatotoxicity and dyslipidemia. Here we demonstrate that EFV stimulates the activation in primary hepatocytes of key cell stress regulators: inositol-requiring 1α (IRE1α) and X-box binding protein 1 (XBP1). Following
Journal of cellular and molecular medicine, 22(7), 3572-3581 (2018-04-20)
Lipotoxicity induced by saturated fatty acids (SFAs) plays a pathological role in the development of non-alcoholic fatty liver disease (NAFLD); however, the exact mechanism(s) remain to be clearly elucidated. Toll-like receptor (TLR) 4 plays a fundamental role in activating the
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.